The domain within your query sequence starts at position and ends at position ; the E-value for the ADF domain shown below is < 1e-12.
ADFActin depolymerisation factor/cofilin -like domains
|SMART accession number:||SM00102|
|Description:||Severs actin filaments and binds to actin monomers.|
|Interpro abstract (IPR002108):|
The actin-depolymerising factor homology (ADF-H) domain is an ~150-amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins [(PUBMED:9693358), (PUBMED:12207032), (PUBMED:9047337)]:
Although these proteins are biochemically distinct and play different roles in actin dynamics, they all appear to use the ADF-H domain for their interactions with actin.
The ADF-H domain consists of a six-stranded mixed beta-sheet in which the four central strands (beta2-beta5) are anti-parallel and the two edge strands (beta1 and beta6) run parallel with the neighbouring strands. The sheet is surrounded by two alpha-helices on each side [(PUBMED:9693358), (PUBMED:12207032), (PUBMED:15522287)].
|GO component:||intracellular (GO:0005622)|
|GO function:||actin binding (GO:0003779)|
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