The domain within your query sequence starts at position and ends at position ; the E-value for the CUE domain shown below is < 1e-12.
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CUEDomain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) |
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| SMART accession number: | SM00546
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| Description: |
CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) |
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| Interpro abstract (IPR003892): |
This domain may be involved in binding ubiquitin-conjugating enzymes (UBCs). CUE domains also occur in two proteins of the IL-1 signal transduction pathway, tollip and TAB2.
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| GO function: | protein binding (GO:0005515) |
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| Family alignment: |
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There are 464
CUE domains in 452 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Biederer T, Volkwein C, Sommer T
- Role of Cue1p in ubiquitination and degradation at the ER surface.
- Science. 1997; 278: 1806-9
- Display abstract
Endoplasmic reticulum (ER) degradation of aberrant proteins is mediated by the ubiquitin-proteasome pathway. Here, a membrane-bound component of the ubiquitin system, Cue1p, was identified. It was shown to recruit the soluble ubiquitin-conjugating enzyme Ubc7p to the ER membrane. In the absence of Cue1p, unassembled and thus cytosolically mislocalized Ubc7p was unable to participate in ER degradation or in the turnover of soluble non-ER proteins. Moreover, ubiquitination by Cue1p-assembled Ubc7p and Ubc6p was a prerequisite for retrograde transport of lumenal substrates out of the ER, which suggests that ubiquitination is mechanistically integrated into the ER degradation process.
- Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath | | % proteins involved | KEGG pathway ID | Description |
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| 66.67 | map04620 | Toll-like receptor signaling pathway | | 29.17 | map04010 | MAPK signaling pathway | | 4.17 |  map00380 | Tryptophan metabolism |
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CUE domain which could be assigned to a KEGG orthologous group, and not all proteins containing CUE domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%. |
- Structure (3D structures containing this domain)
3D Structures of CUE domains in PDB
| PDB code | Main view | Title | | 1mn3 |  | Cue domain of yeast vps9p |
| 1otr |  | Solution structure of a cue-ubiquitin complex |
| 1p3q |  | Mechanism of ubiquitin recognition by the cue domain of vps9 |
| 1wgl |  | Solution structure of cue domain in the c-terminal of human toll-interacting protein (tollip) |
| 2dae |  | Solution structure of the n-terminal cue domain in the human mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (map3k7ip2) |
| 2dhy |  | Solution structure of the cue domain in the human cue domain containing protein 1 (cuedc1) |
| 2di0 |  | Solution structure of the cue domain in the human activating signal cointegrator 1 complex subunit 2 (ascc2) |
| 2ejs |  | Solution structure of ruh-076, a human cue domain |
| 2ekf |  | Solution structure of ruh-075, a human cue domain |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a CUE domain in a specific node, click on it.