Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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The domain within your query sequence starts at position and ends at position ; the E-value for the CheW domain shown below is < 1e-12.

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CheW Two component signalling adaptor domain

SMART accession number:	SM00260
Description:
Interpro abstract (IPR002545):	CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flagellar rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA [(PUBMED:9989504)] binds to CheW, suggesting that these domains can interact with each other.
GO process:	chemotaxis (GO:0006935), signal transduction (GO:0007165)
GO component:	intracellular (GO:0005622)
GO function:	signal transducer activity (GO:0004871)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 4604 CheW domains in 4454 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a CheW domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with CheW domain is also avaliable.

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• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 58.45 map02030 Bacterial chemotaxis - General 33.95 map02020 Two-component system - General 7.52 map03090 Type II secretion system 0.08 map00190 Oxidative phosphorylation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CheW domain which could be assigned to a KEGG orthologous group, and not all proteins containing CheW domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of CheW domains in PDB

  PDB code	Main view	Title
  1b3q		Crystal structure of chea-289, a signal transducing histidine kinase
  1k0s		Solution structure of the chemotaxis protein chew from the thermophilic organism thermotoga maritima
  2ch4		Complex between bacterial chemotaxis histidine kinase chea domains p4 and p5 and receptor-adaptor protein chew
  2ho9		Solution structure of chemotaxi protein chew from escherichia coli
  2qdl		Crystal structure of scaffolding protein ttchew from thermoanaerobacter tengcongensis

• Links (links to other resources describing this domain)

• INTERPRO	IPR002545

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