Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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The domain within your query sequence starts at position and ends at position ; the E-value for the HALZ domain shown below is < 1e-12.

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HALZ homeobox associated leucin zipper

SMART accession number:	SM00340
Description:	-
Interpro abstract (IPR003106):	This region is a plant specific leucine zipper that is always found associated with a homeobox [ (PUBMED:7915839) ].
GO process:	regulation of transcription, DNA-templated (GO:0006355)
GO function:	sequence-specific DNA binding (GO:0043565)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1521 HALZ domains in 1518 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing HALZ domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with HALZ domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing HALZ domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Schena M, Davis RW
  • Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families.
  • Proc Natl Acad Sci U S A. 1994; 91: 8393-7
  • Display abstract

  • Homeobox genes are present in both plants and animals. Homeobox-leucine zipper genes, however, have been identified thus far only in the small mustard plant Arabidopsis thaliana. This observation suggests that homeobox-leucine zipper genes evolved after the divergence of plants and animals, perhaps to mediate specific regulatory events. To better understand this gene family, we isolated several sequences containing the homeobox-leucine zipper motif and carried out a comparative analysis of nine homeobox-leucine zipper genes (HAT1, HAT2, HAT3, HAT4, HAT5, HAT7, HAT9, HAT14, and HAT22). Gene structures, sequence comparisons, and chromosomal locations suggest a simple model for the evolution of these genes. The model postulates that a primordial homeobox gene acquired a leucine zipper by exon capture. The nascent homeobox-leucine zipper gene then appears to have undergone a series of gene duplication and chromosomal translocation events, leading to the formation of the HAT gene family. This work has general implications for the evolution of regulatory genes.

• Links (links to other resources describing this domain)

• INTERPRO	IPR003106

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