Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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The domain within your query sequence starts at position and ends at position ; the E-value for the Hr1 domain shown below is < 1e-12.

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Hr1 Rho effector or protein kinase C-related kinase homology region 1 homologues

SMART accession number:	SM00742
Description:	Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain
Interpro abstract (IPR011072):	The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [(PUBMED:7851406)]. The first two of these repeats were later shown to bind the small G protein rho [(PUBMED:8647255), (PUBMED:9446575)] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [(PUBMED:10619026)]. It forms an antiparallel coiled-coil fold termed an ACC finger.
GO process:	signal transduction (GO:0007165)
GO component:	intracellular (GO:0005622)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 601 Hr1 domains in 293 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a Hr1 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Hr1 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: signalling
  Binding / catalysis: RhoGTP-binding

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 6.12 map04530 Tight junction 6.12 map04370 VEGF signaling pathway 6.12 map04010 MAPK signaling pathway 6.12 map04070 Phosphatidylinositol signaling system 6.12 map04510 Focal adhesion 6.12 map04670 Leukocyte transendothelial migration 6.12 map04012 ErbB signaling pathway 6.12 map05214 Glioma 6.12 map04310 Wnt signaling pathway 6.12 map04540 Gap junction 6.12 map04020 Calcium signaling pathway 6.12 map04720 Long-term potentiation 6.12 map04916 Melanogenesis 6.12 map04730 Long-term depression 6.12 map05223 Non-small cell lung cancer 6.12 map04650 Natural killer cell mediated cytotoxicity 1.02 map00562 Inositol phosphate metabolism 1.02 map00632 Benzoate degradation via CoA ligation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Hr1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Hr1 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of Hr1 domains in PDB

  PDB code	Main view	Title
  1cxz		Crystal structure of human rhoa complexed with the effector domain of the protein kinase pkn/prk1
  1urf		Hr1b domain from prk1
  2rmk		Rac1/prk1 complex

• Links (links to other resources describing this domain)

• PFAM	HR1
  INTERPRO	IPR011072

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