Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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The domain within your query sequence starts at position and ends at position ; the E-value for the HSA domain shown below is < 1e-12.

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HSA domain in helicases and associated with SANT domains

SMART accession number:	SM00573
Description:
Interpro abstract (IPR013999):	This domain of unknown function is found in helicases and other DNA-binding proteins of eukaryotes [(PUBMED:11779830)]. This entry occurs in the same type of proteins as IPR006562, but has fewer matches.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 183 HSA domains in 183 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a HSA domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with HSA domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Binding / catalysis: DNA-binding

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
  • Systematic identification of novel protein domain families associated with nuclear functions.
  • Genome Res. 2002; 12: 47-56
  • Display abstract

  • A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 40.00 map00500 Starch and sucrose metabolism 40.00 map00790 Folate biosynthesis 20.00 map00230 Purine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HSA domain which could be assigned to a KEGG orthologous group, and not all proteins containing HSA domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• INTERPRO	IPR013999

Send comments to Ivica Letunic