The domain within your query sequence starts at position and ends at position ; the E-value for the IQ domain shown below is < 1e-12.
IQShort calmodulin-binding motif containing conserved Ile and Gln residues.
|SMART accession number:||SM00015|
|Interpro abstract (IPR000048):|
The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins including the essential and regulatory myosin light chains, calmodulin (CaM), and CaM-like proteins [(PUBMED:1558751), (PUBMED:9141499)].Many IQ motifs are protein kinase C (PKC) phosphorylation sites [(PUBMED:1824695), (PUBMED:8424932)].
Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix [(PUBMED:8127365)].
Some proteins known to contain an IQ motif are listed below:
This entry covers the entire IQ motif.
|GO function:||protein binding (GO:0005515)|
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- Evolution (species in which this domain is found)
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- Disease (disease genes where sequence variants are found in this domain)
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- Structure (3D structures containing this domain)
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