The domain within your query sequence starts at position and ends at position ; the E-value for the ITAM domain shown below is < 1e-12.

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ITAM

Immunoreceptor tyrosine-based activation motif
ITAM
SMART accession number:SM00077
Description: Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.
Interpro abstract (IPR003110):

Phosphorylated immunoreceptor signalling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases [(PUBMED:7594458)]. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.

GO process:cell surface receptor signaling pathway (GO:0007166)
GO component:membrane (GO:0016020)
GO function:transmembrane signaling receptor activity (GO:0004888)
Family alignment:
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There are 786 ITAM domains in 578 proteins in SMART's nrdb database.

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