The domain within your query sequence starts at position and ends at position ; the E-value for the OLF domain shown below is < 1e-12.
|SMART accession number:||SM00284|
|Interpro abstract (IPR003112):|
The olfactomedin-domain was first identified in olfactomedin, an extracellular matrix protein of the olfactory neuroepithelium [(PUBMED:12615070)]. Members of this extracellular domain-family have since been shown to be present in several metazoan proteins, such as latrophilins, myocilins, optimedins and noelins, the latter being involved in the generation of neural crest cells. Myocilin is of considerable interest, as mutations in its olfactomedin-domain can lead to glaucoma [(PUBMED:14764620)]. The olfactomedin-domains in myocilin and optimedin are essential for the interaction between these two proteins [(PUBMED:12019210)].
|GO function:||protein binding (GO:0005515)|
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Disease (disease genes where sequence variants are found in this domain)
- Links (links to other resources describing this domain)