The domain within your query sequence starts at position and ends at position ; the E-value for the UBCc domain shown below is < 1e-12.

Some of the required catalytic sites were not detected in this domain. It is probably inactive! Check the literature (PubMed 97407928 ) for details.

Catalytic residues
PositionAmino acidPresent?


Ubiquitin-conjugating enzyme E2, catalytic domain homologues
SMART accession number:SM00212
Description: Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.
Family alignment:
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There are 13547 UBCc domains in 13479 proteins in SMART's nrdb database.

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