AAA

ATPases associated with a variety of cellular activities
AAA
SMART accession number:SM00382
Description: AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Interpro abstract (IPR003593):

The AAA+ superfamily of ATPases is found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Although the terms AAA+ and AAA are often used loosely and interchangeably, the classical AAA family members are distinguished by their possession of the SRH region in the AAA module. Many AAA+ proteins are involved in similar processes to those of AAA proteins (facilitation of protein folding and unfolding, assembly or disassembly of proteins complexes, protein transport and degradation), but others function in replication, recombination, repair and transcription. For a review see [(PUBMED:11473577)].

The proteins in this superfamily are characterised by the structural conservation of a central ATPase domain of about 250 amino acids called the AAA+ module. Typically, the AAA+ domain can be divided into two structural subdomains, an N-terminal P-loop NTPase alpha-beta-alpha subdomain that is connected to a smaller C-terminal all-alpha subdomain. The alpha-beta-alpha subdomain adopts a Rossman fold and contains several motifs involved in ATP binding and hydrolysis, including classical motifs Walker A and Walker B [(PUBMED:11473577), (PUBMED:18466635)]. The all-alpha subdomain [(PUBMED:9927482)], is much less conserved across AAA+ proteins.

GO function:nucleoside-triphosphatase activity (GO:0017111), nucleotide binding (GO:0000166)
Family alignment:
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There are 762064 AAA domains in 656602 proteins in SMART's nrdb database.

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