Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

AHS2 Allophanate hydrolase subunit 2

SMART accession number:	SM00797
Description:	This domain represents subunit 2 of allophanate hydrolase (AHS2).
Interpro abstract (IPR003778):	Allophanate hydrolase catalyses the second reaction in an ATP-dependent, two-step degradation of urea to ammonia and C02. This follows the action of the biotin-containing urea carboxylase. Saccharomyces cerevisiae can use urea as a sole nitrogen source via this degradation pathway [(PUBMED:6124544)]. In yeast, the fusion of allophanate hydrolase to urea carboxylase is called urea amidolyase. In bacteria, the second step in the urea degradation pathway is also the ATP-dependent allophanate hydrolase. The gene encoding this enzyme is found adjacent to the urea carboxylase gene [(PUBMED:15796980)]. Allophanate hydrolase has strict substrate specificity, as analogues of allophanate are not hydrolysed by it [(PUBMED:15796980)]. This domain represents subunit 2 of allophanate hydrolase (AHS2) which is found in urea carboxylase.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 0 AHS2 domains in 0 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a AHS2 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with AHS2 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 56.99 map00220 Urea cycle and metabolism of amino groups 40.86 map00791 Atrazine degradation 1.08 map00640 Propanoate metabolism 1.08 map00280 Valine, leucine and isoleucine degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with AHS2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing AHS2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• PFAM	AHS2
  INTERPRO	IPR003778

Send comments to Ivica Letunic