SMART: AMOP domain annotation

AMOP Adhesion-associated domain present in MUC4 and other proteins

SMART accession number:	SM00723
Description:
Interpro abstract (IPR005533):	This domain may have a role in cell adhesion [(PUBMED:11893501)]. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.
Family alignment:	View or

There are 121 AMOP domains in 120 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with AMOP domain is also avaliable.

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Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Ciccarelli FD, Doerks T, Bork P
- AMOP, a protein module alternatively spliced in cancer cells.
- Trends Biochem Sci. 2002; 27: 113-5
- Display abstract
- This article describes a new extracellular domain--AMOP, for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.
Links (links to other resources describing this domain)
INTERPRO IPR005533