AP2DNA-binding domain in plant proteins such as APETALA2 and EREBPs
|SMART accession number:||SM00380|
|Interpro abstract (IPR001471):|
Ethylene is an endogenous plant hormone that influences many aspects of plant growth and development. Some defense related genes that are induced by ethylene contain a cis-regulatory element known as the Ethylene- Responsive Element (ERE) [(PUBMED:2535512)]. Sequence analysis on various ERE regions has identified a short motif rich in G/C nucleotides, the GCC-box, essential for the response to ethylene. This short motif is recognised by a family of transcrition factors, the ERE binding factors (ERF) [(PUBMED:10715325)].
ERF proteins contain a domain of around 60 amino acids which is also found in the APETALA2 (AP2) protein [(PUBMED:7773013)]. This AP2/ERF domain has been shown in various proteins to be necessary and sufficient to bind the GCC-box [(PUBMED:9756931)].
The structure of the AP2/ERF domain in complex with the target DNA has been solved [(PUBMED:9736626)]. The structure resembles that of bacteriophage integrases and the methyl-CpG-binding domain (MBD): a three-stranded beta-sheet and an alpha helix almost parallel to the beta-sheet. It contacts DNA via Arg and Trp residues located in the beta- sheet.
Some proteins known to contain an AP2/ERF domain include:
This entry represents the AP2/ERF domain.
|GO process:||regulation of transcription, DNA-templated (GO:0006355)|
|GO function:||sequence-specific DNA binding transcription factor activity (GO:0003700)|
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- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
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