A_amylase_inhib

Alpha amylase inhibitor
A_amylase_inhib
SMART accession number:SM00783
Description: Alpha amylase inhibitor inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. The inhibitor has no action on plant and microbial alpha amylases.
Interpro abstract (IPR000833):

Alpha-amylase inhibitor inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. The inhibitor has no action on plant and microbial alpha amylases.

A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces tendae that targets a wide range of mammalian alpha-amylases [(PUBMED:14501112)]. The binding of tendamistat to alpha-amylase leads to the steric blockage of the active site of the enzyme. The crystal structure of tendamistat revealed an immunoglobulin-like fold that could potentially adopt multiple conformations. Such molecular flexibility could enable an induced-fit type of binding that would both optimise binding and allow broad target specificity.

More information about this protein can be found at Protein of the Month: alpha-Amylase [].

GO function:alpha-amylase inhibitor activity (GO:0015066)
Family alignment:
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There are 11 A_amylase_inhib domains in 11 proteins in SMART's nrdb database.

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