S-adenosyl-L-homocysteine hydrolase
SMART accession number:SM00996
Description: -
Interpro abstract (IPR000043):

Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, EC (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding.

GO process:one-carbon metabolic process (GO:0006730)
GO function:adenosylhomocysteinase activity (GO:0004013)
Family alignment:
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There are 3899 AdoHcyase domains in 3832 proteins in SMART's nrdb database.

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