Aerolysin

Aerolysin toxin
Aerolysin
SMART accession number:SM00999
Description: This family represents the pore forming lobe of aerolysin.
Interpro abstract (IPR005832):

Aerolysin [(PUBMED:3584074)] is a cytolytic toxin exported by Aeromonas hydrophila, a Gram-negative bacterium associated with diarrhoeal diseases and deep wound infections [(PUBMED:7510043)]. The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. The structure of proaerolysin has been determined to 2.8A resolution and shows the protoxin to adopt a novel fold [(PUBMED:7510043)]. Images of an aerolysin oligomer derived from electron microscopy have helped to construct a model of the protein and to outline a mechanism by which it might insert into lipid bilayers to form ion channels [(PUBMED:7510043)].

Staphylococcus aureus also exports a cytotoxin, alpha-toxin [(PUBMED:6500704)], whose biological activity is similar to that of aerolysin. The sequences of both toxins are not similar except for a stretch of ten residues rather well conserved.

Pseudomonas aeruginosa cytotoxin [(PUBMED:2507866)] contain a region whose sequence is similar to that of the conserved domain of areolysin/alpha- toxin, but the similarity is very weak.

GO process:pathogenesis (GO:0009405)
GO component:extracellular region (GO:0005576)
Family alignment:
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There are 18 Aerolysin domains in 18 proteins in SMART's nrdb database.

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