|SMART accession number:||SM00999|
|Description:||This family represents the pore forming lobe of aerolysin.|
|Interpro abstract (IPR005832):|
Aerolysin [(PUBMED:3584074)] is a cytolytic toxin exported by Aeromonas hydrophila, a Gram-negative bacterium associated with diarrhoeal diseases and deep wound infections [(PUBMED:7510043)]. The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. The structure of proaerolysin has been determined to 2.8A resolution and shows the protoxin to adopt a novel fold [(PUBMED:7510043)]. Images of an aerolysin oligomer derived from electron microscopy have helped to construct a model of the protein and to outline a mechanism by which it might insert into lipid bilayers to form ion channels [(PUBMED:7510043)].
Staphylococcus aureus also exports a cytotoxin, alpha-toxin [(PUBMED:6500704)], whose biological activity is similar to that of aerolysin. The sequences of both toxins are not similar except for a stretch of ten residues rather well conserved.
|GO process:||pathogenesis (GO:0009405)|
|GO component:||extracellular region (GO:0005576)|
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)