Agouti

Agouti protein
Agouti
SMART accession number:SM00792
Description: The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation (PUBMED:11837451), (PUBMED:11833005).
Interpro abstract (IPR007733): The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation [(PUBMED:11837451), (PUBMED:11833005)]. This family also includes the Agouti-related protein (Agrp), involved in energy balance, body weight regulation and metabolism. It interacts with melanocortin receptors MC3R, MC4R and MC5R [(PUBMED:9892020)].
GO process:hormone-mediated signaling pathway (GO:0009755)
GO component:extracellular region (GO:0005576)
Family alignment:
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There are 271 Agouti domains in 271 proteins in SMART's nrdb database.

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