Alpha_kinase

Alpha-kinase family
Alpha_kinase
SMART accession number:SM00811
Description: This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.
Interpro abstract (IPR004166): Proteins containing this domain consist of a novel group of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. Proteins include myosin heavy chain kinases [(PUBMED:7822274), (PUBMED:9054368)] and Elongation Factor-2 kinase and a bifunctional ion channel [(PUBMED:11161216)].
GO process:protein phosphorylation (GO:0006468)
GO function:protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524)
Family alignment:
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There are 303 Alpha_kinase domains in 297 proteins in SMART's nrdb database.

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