Ami_2

Ami_2
SMART accession number:SM00644
Description: -
Interpro abstract (IPR002502): Proteins containing this domain include zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC 3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The bacteriophage endolysins PLY118 and PLY500 cleave between L-Ala and D-Glu residues of Listeria cell-wall peptidoglycan and are therefore peptidases (MEROPS subfamily M15C) [(PUBMED:8577256)]. The structure is known for the Bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding [(PUBMED:14506276), (PUBMED:12845326), (PUBMED:8171031), (PUBMED:15223330), (PUBMED:16556841), (PUBMED:18304640), (PUBMED:15140887), (PUBMED:16103125), (PUBMED:16428381)].
GO process:peptidoglycan catabolic process (GO:0009253)
GO function:N-acetylmuramoyl-L-alanine amidase activity (GO:0008745)
Family alignment:
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There are 27919 Ami_2 domains in 27615 proteins in SMART's nrdb database.

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