|SMART accession number:||SM01351
||This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054 His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner (PMID:11679721).|
There are 205 Aspzincin_M35 domains in 205 proteins in SMART's nrdb database.
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