B2-adapt-app_C

Beta2-adaptin appendage, C-terminal sub-domain
B2-adapt-app_C
SMART accession number:SM01020
Description: Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
Interpro abstract (IPR015151):

This entry represents a subdomain of the appendage (ear) domain of beta-adaptin. This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet [(PUBMED:10430869)]. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [(PUBMED:10944104)].

GO process:intracellular protein transport (GO:0006886), vesicle-mediated transport (GO:0016192)
GO component:clathrin adaptor complex (GO:0030131)
Family alignment:
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There are 186 B2-adapt-app_C domains in 186 proteins in SMART's nrdb database.

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