BACKBTB And C-terminal Kelch
|SMART accession number:||SM00875|
|Description:||The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.|
|Interpro abstract (IPR011705):|
This domain is found associated with (IPR000210) and (IPR006652). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [(PUBMED:16207353)]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB fold is highly conserved.
BTB-Kelch proteins have Kelch repeats that form a beta-propeller that can interact with actin filaments [(PUBMED:15544948)]. BTB and C-terminal Kelch (BACK) together constitute a novel conserved domain, which is thought to have a possible role in substrate orientation in Cullin3-based E3 ligase complexes.
Four domains, namely the BTB domain, a kelch domain, a BACK domain, and an intervening region (IVR) make up the aryl hydrocarbon receptor (AHR); a ligand-activated transcription factor [(PUBMED:16582008)]. This entry represents the domain associated with BTB and Kelch.
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