Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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BID_2 Bacterial Ig-like domain 2

SMART accession number:	SM00635
Description:
Interpro abstract (IPR003343):	Proteins that contain this domain are found in a variety of bacterial and phage surface proteins such as intimins as well as in some uncharacterised eukaryote proteins. Intimin is a bacterial cell-adhesion molecule that mediates the intimate bacterial host-cell interaction. It contains three domains; two immunoglobulin-like domains and a C-type lectin-like module implying that carbohydrate recognition may be important in intimin-mediated cell adhesion [(PUBMED:10201396)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 2673 BID_2 domains in 1167 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a BID_2 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with BID_2 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Arabidopsis thaliana, Caenorhabditis elegans, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 40.00 map00530 Aminosugars metabolism 40.00 map00051 Fructose and mannose metabolism 20.00 map00500 Starch and sucrose metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with BID_2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing BID_2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of BID_2 domains in PDB

  PDB code	Main view	Title
  1cwv		Crystal structure of invasin: a bacterial integrin-binding protein
  1e5u		Nmr representative structure of intimin-190 (int190) from enteropathogenic e. coli
  1f00		Crystal structure of c-terminal 282-residue fragment of enteropathogenic e. coli intimin
  1f02		Crystal structure of c-terminal 282-residue fragment of intimin in complex with translocated intimin receptor (tir) intimin-binding domain
  2zqk		Crystal structure of intimin-tir68 complex

• Links (links to other resources describing this domain)

• PFAM	Big_2
  INTERPRO	IPR003343

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