Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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BRK domain in transcription and CHROMO domain helicases

SMART accession number:	SM00592
Description:
Interpro abstract (IPR006576):	BRK is a domain of unknown function found only in the metazoa and in association with CHROMO domain (IPR000953) and DEAD/DEAH box helicase domain (IPR011545).
GO function:	protein binding (GO:0005515), hydrolase activity, acting on acid anhydrides (GO:0016817)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 290 BRK domains in 219 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a BRK domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with BRK domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
  • Systematic identification of novel protein domain families associated with nuclear functions.
  • Genome Res. 2002; 12: 47-56
  • Display abstract

  • A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 60.00 map04310 Wnt signaling pathway 20.00 map00230 Purine metabolism 10.00 map00500 Starch and sucrose metabolism 10.00 map00790 Folate biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with BRK domain which could be assigned to a KEGG orthologous group, and not all proteins containing BRK domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of BRK domains in PDB

  PDB code	Main view	Title
  2cka		Solution structures of the brk domains of the human chromo helicase domain 7 and 8, reveals structural similarity with gyf domain suggesting a role in protein interaction
  2ckc		Solution structures of the brk domains of the human chromo helicase domain 7 and 8, reveals structural similarity with gyf domain suggesting a role in protein interaction
  2dl6		Solution structure of the first brk domain from human chromodomain-helicase-dna-binding protein 8
  2v0e		Brk domain from human chd7
  2v0f		Brk domain from human chd7

• Links (links to other resources describing this domain)

• INTERPRO	IPR006576

Send comments to Ivica Letunic