bromo domain
SMART accession number:SM00297
Description: -
Interpro abstract (IPR001487): Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [(PUBMED:1350857)]. Bromodomains can interact with acetylated lysine [(PUBMED:9175470)]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [(PUBMED:7580139)].

GO function:protein binding (GO:0005515)
Family alignment:
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There are 14324 BROMO domains in 10766 proteins in SMART's nrdb database.

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