BSDdomain in transcription factors and synapse-associated proteins |
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| SMART accession number: | SM00751
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| Description: |
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| Interpro abstract (IPR005607): |
The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. The function of the BSD domain is yet unknown [(PUBMED:11943536)]. Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain [(PUBMED:11943536)]. Some proteins known to contain one or two BSD domains are listed below: Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1). Yeast RNA polymerase II transcription factor B 73 kDa subunit (TFB1), the homologue of BTF2. Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination. Drosophila synapse-associated protein SAP47. Mammalian SYAP1. Various Arabidopsis thaliana (Mouse-ear cress) hypothetical proteins.
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| Family alignment: |
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There are 555
BSD domains in 418 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Cellular role: transcription
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Doerks T, Huber S, Buchner E, Bork P
- BSD: a novel domain in transcription factors and synapse-associated proteins.
- Trends Biochem Sci. 2002; 27: 168-70
- Display abstract
This article describes a novel domain, BSD, that is present in basal transcription factors, synapse-associated proteins and several hypothetical proteins. It occurs in a variety of species ranging from primal protozoan to human. The BSD domain is characterized by three predicted alpha helices, which probably form a three-helical bundle, as well as by conserved tryptophan and phenylalanine residues, located at the C terminus of the domain.
- Metabolism (metabolic pathways involving proteins which contain this domain)
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| % proteins involved | KEGG pathway ID | Description |
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| 100.00 | map03022 | Basal transcription factors |
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with BSD domain which could be assigned to a KEGG orthologous group, and not all proteins containing BSD domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%. |
- Structure (3D structures containing this domain)
3D Structures of BSD domains in PDB
| PDB code | Main view | Title | | 1x3a |  | Solution structure of the bsd domain of human synapse associated protein 1 |
| 2dii |  | Solution structure of the bsd domain of human tfiih basal transcription factor complex p62 subunit |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a BSD domain in a specific node, click on it.