BURP

BURP
SMART accession number:SM01045
Description: The BURP domain is found at the C-terminus of several different plant proteins. It was named after the proteins in which it was first identified: the BNM2 clone-derived protein from Brassica napus O65009; USPs and USP-like proteins P21746 P21747 Q06765 O24482; RD22 from Arabidopsis thaliana Q08298; and PG1beta from Lycopersicon esculentum Q40161. This domain is around 230 amino acid residues long. It possesses the following conserved features: two phenylalanine residues at its N-terminus; two cysteine residues; and four repeated cysteine-histidine motifs, arranged as: CH-X(10)-CH-X(25-27)-CH-X(25-26)-CH, where X can be any amino acid (PUBMED:9790599). The function of this domain is unknown.
Interpro abstract (IPR004873):

The BURP domain was named after the proteins in which it was first identified: BNM2, USP, RD22, and PG1beta. It is found in the C terminus of a number of plant cell wall proteins, which are defined not only by the BURP domain, but also by the overall similarity in their modular construction. The BURP domain-containing proteins consists of either three or four modules: (i) an N-terminal hydrophobic domain - a presumptive transit peptide, joined to (ii) a short conserved segment or other short segment, (iii) an optional segment consisting of repeated units which is unique to each member, and (iv) the C-terminal BURP domain. Although the BURP domain proteins share primary structural features, their expression patterns and the conditions under which they are expressed differ. The presence of the conserved BURP domain in diverse plant proteins suggests an important and fundamental functional role for this domain [(PUBMED:9790599)]. It is possible that the BURP domain represents a general motif for localization of proteins within the cell wall matrix. The other structural domains associated with the BURP domain may specify other target sites for intermolecular interactions [(PUBMED:12172833)].

Some proteins known to contain a BURP domain are listed below [(PUBMED:9790599), (PUBMED:12172833), (PUBMED:14612572)]:

  • Brassica protein BNM2, which is expressed during the induction of microspore embryogenesis.
  • Field bean USPs, abundant non-storage seed proteins with unknown function.
  • Soybean USP-like proteins ADR6 (or SALI5-4A), an auxin-repressible, aluminium-inducible protein and SALI3-2, a protein that is up-regulated by aluminium.
  • Soybean seed coat BURP-domain protein 1 (SCB1). It might play a role in the differentiation of the seed coat parenchyma cells.
  • Arabidopsis RD22 drought induced protein.
  • Maize ZRP2, a protein of unknown function in cortex parenchyma.
  • Tomato PG1beta, the beta-subunit of polygalacturonase isozyme 1 (PG1), which is expressed in ripening fruits.
  • Cereal RAFTIN. It is essential specifically for the maturation phase of pollen development.

Family alignment:
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There are 15 BURP domains in 13 proteins in SMART's nrdb database.

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