Bac_DnaA_C

Bacterial dnaA protein helix-turn-helix domain
Bac_DnaA_C
SMART accession number:SM00760
Description: Could be involved in DNA-binding.
Interpro abstract (IPR013159):

This entry represents the C-terminal domain of bacterial DnaA proteins [(PUBMED:8110826), (PUBMED:1779750), (PUBMED:2558436)] that play an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).

DnaA is a protein of about 50 kDa that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. The protein may also bind the RNA polymerase beta subunit, the dnaB and dnaZ proteins, and the groE gene products (chaperonins) [(PUBMED:2172087)].

GO process:regulation of DNA replication (GO:0006275), DNA replication initiation (GO:0006270)
GO function:sequence-specific DNA binding (GO:0043565), ATP binding (GO:0005524)
Family alignment:
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There are 1647 Bac_DnaA_C domains in 1646 proteins in SMART's nrdb database.

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