BRO family, N-terminal domain
SMART accession number:SM01040
Description: This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription (PUBMED:10888617). This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins (PUBMED:9847359).
Interpro abstract (IPR003497):

The baculovirus Bro proteins are encoded by a multigene family. The typical Bro proteins that have been experimentally investigated are BroA, BroC and BroD from Bombyx mori uclear polyhedrosis virus (BmNV). They contain distinct amino- and carboxy-terminal domains (Bro-N and Bro-C, respectively) that are present independently of each other and in distinct contexts in a variety of other viral proteins. The Bro-N domain occurs in a stand-alone form or combined with other domains in proteins from temperate phages that infect Gram-positive bacteria and Myxococcus xanthus, and proteins encoded in the genomes of proteobacteria and Gram positive bacteria. The Bro-N domain appears to define a distinct superfamily of widespread viral DNA-binding domains [(PUBMED:11897024)].

Family alignment:
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There are 9233 Bro-N domains in 9155 proteins in SMART's nrdb database.

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