C1_4

TFIIH C1-like domain
C1_4
SMART accession number:SM01047
Description: The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (PUBMED:10882739).
Interpro abstract (IPR004595):

The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domains. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C [(PUBMED:10882739)].

GO process:DNA repair (GO:0006281)
GO function:zinc ion binding (GO:0008270)
Family alignment:
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There are 365 C1_4 domains in 361 proteins in SMART's nrdb database.

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