Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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CAD Domains present in proteins implicated in post-mortem DNA fragmentation

SMART accession number:	SM00266
Description:
Interpro abstract (IPR003508):	This domain consists of caspase-activated (CAD) nucleases, which induce DNA fragmentation and chromatin condensation during apoptosis, and the cell death activator proteins CIDE-A and CIDE-B, which are inhibitors of CAD nuclease. The two proteins interact through the region defined by the method signatures.
GO process:	apoptotic process (GO:0006915)
GO component:	intracellular (GO:0005622)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 155 CAD domains in 155 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a CAD domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with CAD domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 100.00 map04210 Apoptosis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CAD domain which could be assigned to a KEGG orthologous group, and not all proteins containing CAD domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of CAD domains in PDB

  PDB code	Main view	Title
  1c9f		Nmr structure of the cad domain of caspase-activated dnase
  1d4b		Cide-n domain of human cide-b
  1f2r		Nmr structure of the heterodimeric complex between cad domains of cad and icad
  1ibx		Nmr structure of dff40 and dff45 n-terminal domain complex
  1v0d		Crystal structure of caspase-activated dnase (cad)
  2eel		Solution structure of the cide-n domain of human cell death activator cide-a

• Links (links to other resources describing this domain)

• INTERPRO	IPR003508

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