SMART: CARP domain annotation

CARP Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product.

SMART accession number:	SM00673
Description:
Interpro abstract (IPR006599):	This entry represents the CARP motif, which occurs as a tandem repeat in the C-terminal of many cyclase-associated proteins (CAPs), as well as in tubulin binding cofactor C and the X-linked retinitis pigmentosa 2 protein (RP2).
Family alignment:	View or

There are 977 CARP domains in 522 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a CARP domain in a specific node, click on it.

This tree shows only several representative species. The complete taxonomic breakdown of all proteins with CARP domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: signalling
Binding / catalysis: Proper folding of tubulin?
Structure (3D structures containing this domain)

PDB code	Main view	Title
1k4z		C-terminal domain of cyclase associated protein
1k8f		Crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein
1kq5		C-terminal domain of cyclase associated protein with pro replaced by ser (p505s)
2b0r		Crystal structure of cyclase-associated protein from cryptosporidium parvum
2bx6		Crystal structure of the human retinitis pigmentosa protein 2 (rp2)
2yuh		Solution structure of the c-terminal region in human tubulin folding cofactor c
3bh6		Crystal structure of the rp2-arl3 complex bound to gppnhp
3bh7		Crystal structure of the rp2-arl3 complex bound to gdp-alf4

CARP