CBFCCAAT-Binding transcription Factor
|SMART accession number:||SM00521|
|Interpro abstract (IPR001289):||The CCAAT-binding factor (CBFB/NF-YA) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin [(PUBMED:2266139)]. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding [(PUBMED:1549471)]. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction. |
The B subunit contains a region of similarity with the yeast protein HAP2 [(PUBMED:2000400)]. For the B subunit it has been suggested that the N-terminal portion of the conserved region is involved in subunit interaction and the C-terminal region involved in DNA-binding [(PUBMED:1569083)].
|GO process:||regulation of transcription, DNA-dependent (GO:0006355)|
|GO component:||nucleus (GO:0005634)|
|GO function:||sequence-specific DNA binding transcription factor activity (GO:0003700)|
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