CBM_10

Cellulose or protein binding domain
CBM_10
SMART accession number:SM01064
Description: This domain is found in two distinct sets of proteins with different functions. Those found in aerobic bacteria bind cellulose (or other carbohydrates); but in anaerobic fungi they are protein binding domains, referred to as dockerin domains or docking domains. They are believed to be responsible for the assembly of a multiprotein cellulase/hemicellulase complex, similar to the cellulosome found in certain anaerobic bacteria.
Interpro abstract (IPR009031):

Plant cell wall hydrolases from aerobic microorganisms generally have a modular structure consisting of a catalytic domain linked to one or more carbohydrate-binding modules (CBMs). CBMs function to attach the enzyme to the polymeric substrate, thereby increasing the catalytic activity. Most CBMs bind cellulose and are referred to as cellulose-binding domains (CBDs), while some can also bind xylan.

The structure of CBM10 from Pseudomonas Xylanase A has been solved [(PUBMED:10653641)]. The domain consists largely of beta-sheet with three aromatic residues (Tyr8, Trp 22, and Trp24) that are exposed and approximately coplanar and well placed to interact with cellulose.

GO process:carbohydrate metabolic process (GO:0005975)
GO function:cellulose binding (GO:0030248)
Family alignment:
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There are 64 CBM_10 domains in 44 proteins in SMART's nrdb database.

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