CBS

Domain in cystathionine beta-synthase and other proteins.
CBS
SMART accession number:SM00116
Description: Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure [3]. A number of disease states are associated with CBS-containing proteins including homocystinuria, Becker's and Thomsen disease.
Interpro abstract (IPR000644):

CBS domains are small intracellular modules that pair together to form a stable globular domain [(PUBMED:10200156)]. Pairs of these domains have been termed a Bateman domain [(PUBMED:14722609)]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [(PUBMED:14722619)]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet [(PUBMED:11524006)]. CBS domain pairs from AMPK bind AMP or ATP [(PUBMED:14722619)]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [(PUBMED:14722619)].

Family alignment:
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There are 98690 CBS domains in 53724 proteins in SMART's nrdb database.

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