CHZ

Histone chaperone domain CHZ
CHZ
SMART accession number:SM01082
Description: This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones (PUBMED:17289584).
Interpro abstract (IPR019098):

This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [(PUBMED:17289584)].

Family alignment:
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There are 316 CHZ domains in 316 proteins in SMART's nrdb database.

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