Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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CKS Cyclin-dependent kinase regulatory subunit

SMART accession number:	SM01084
Description:	Cyclin-dependent kinase regulatory subunit.
Interpro abstract (IPR000789):	In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [(PUBMED:3322810)]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [(PUBMED:8211159)]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [(PUBMED:8491379)]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [(PUBMED:8491379), (PUBMED:8211159)].
GO process:	cell cycle (GO:0007049)
GO function:	cyclin-dependent protein kinase regulator activity (GO:0016538)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 253 CKS domains in 253 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a CKS domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with CKS domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Structure (3D structures containing this domain)

• 3D Structures of CKS domains in PDB

  PDB code	Main view	Title
  1buh		Crystal structure of the human cdk2 kinase complex with cell cycle-regulatory protein ckshs1
  1cks		Human ckshs2 atomic structure: a role for its hexameric assembly in cell cycle control
  1dks		Ckshs1: human cyclin dependent kinase subunit, type 1 in complex with phosphate
  1dkt		Ckshs1: human cyclin dependent kinase subunit, type 1 complex with metavanadate
  1puc		P13suc1 in a strand-exchanged dimer
  1qb3		Crystal structure of the cell cycle regulatory protein cks1
  1sce		Crystal structure of the cell cycle regulatory protein suc1 reveals a novel beta-hinge conformational switch
  2ass		Crystal structure of the skp1-skp2-cks1 complex
  2ast		Crystal structure of skp1-skp2-cks1 in complex with a p27 peptide

• Links (links to other resources describing this domain)

• PFAM	CKS
  INTERPRO	IPR000789

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