CLECTC-type lectin (CTL) or carbohydrate-recognition domain (CRD) |
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| SMART accession number: | SM00034 |
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| Description: | Many of these domains function as calcium-dependent carbohydrate binding modules. |
| Interpro abstract (IPR001304): | Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [(PUBMED:14533786)], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions [(PUBMED:12223269)]. There are at least twelve structural families of lectins:
C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [(PUBMED:15476922)]. Therefore, lectins are a diverse group of proteins, both in terms of structure and activity. Carbohydrate binding ability may have evolved independently and sporadically in numerous unrelated families, where each evolved a structure that was conserved to fulfil some other activity and function. In general, animal lectins act as recognition molecules within the immune system, their functions involving defence against pathogens, cell trafficking, immune regulation and the prevention of autoimmunity [(PUBMED:14519388)]. |
| GO function: | carbohydrate binding (GO:0030246) |
| Family alignment: |
There are 8112 CLECT domains in 6129 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes - Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Elgavish S, Shaanan B
- Lectin-carbohydrate interactions: different folds, common recognition principles.
- Trends Biochem Sci. 1997; 22: 462-7
- Display abstract
Lectins can be found in many organisms and are involved in a multitude of cellular processes that depend on specific recognition of complex carbohydrates. The stereochemical principles underlying the recognition process have been the subject of extensive biochemical and structural studies. When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site.
- Weis WI, Drickamer K
- Structural basis of lectin-carbohydrate recognition.
- Annu Rev Biochem. 1996; 65: 441-73
- Display abstract
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cell-cell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar recognition by members of all of these groups has been investigated by x-ray crystallography. Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. Relatively low affinity binding sites for monosaccharides are formed at shallow indentations on protein surfaces. Selectivity is achieved through a combination of hydrogen bonding to the sugar hydroxyl groups with van der Waals packing, often including packing of a hydrophobic sugar face against aromatic amino acid side chains. Higher selectivity of binding is achieved by extending binding sites through additional direct and water-mediated contacts between oligosaccharides and the protein surface. Dramatically increased affinity for oligosaccharides results from clustering of simple binding sites in oligomers of the lectin polypeptides. The geometry of such oligomers helps to establish the ability of the lectins to distinguish surface arrays of polysaccharides in some instances and to crosslink glycoconjugates in others.
- Holmskov U, Malhotra R, Sim RB, Jensenius JC
- Collectins: collagenous C-type lectins of the innate immune defense system.
- Immunol Today. 1994; 15: 67-74
- Display abstract
Collectins are humoral lectins found in mammals and birds. They are oligomers whose subunits comprise three polypeptide chains each containing a collagenous section and a C-terminal lectin domain. They are related structurally and functionally to the first component of the classical complement pathway, C1q, and seem to serve important roles in innate immunity through opsonization and complement activation. The lectin domains bind carbohydrates on microorganisms, while the collagenous regions are ligands for the collectin receptor on phagocytes and also mediate C1q-independent activation of the classical complement pathway.
- Drickamer K
- Two distinct classes of carbohydrate-recognition domains in animal lectins.
- J Biol Chem. 1988; 263: 9557-60
- Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 25.00 map04650 Natural killer cell mediated cytotoxicity 20.69 map04514 Cell adhesion molecules (CAMs) 19.83 map04610 Complement and coagulation cascades 18.97 map04612 Antigen processing and presentation 6.03 map03320 PPAR signaling pathway 5.17 map04662 B cell receptor signaling pathway 3.45 map04640 Hematopoietic cell lineage 0.86 
map00252Alanine and aspartate metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CLECT domain which could be assigned to a KEGG orthologous group, and not all proteins containing CLECT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of CLECT domains in PDB
PDB code Main view Title 1afa 
Structural basis of galactose recognition in c-type animal lectins 1afb 
Structural basis of galactose recognition in c-type animal lectins 1afd 
Structural basis of galactose recognition in c-type animal lectins 1b08 
Lung surfactant protein d (sp-d) (fragment) 1b6e 
Human cd94 1bch 
Mannose-binding protein-a mutant (qpdwgh) complexed with n- acetyl-d-galactosamine 1bcj 
Mannose-binding protein-a mutant (qpdwghv) complexed with n- acetyl-d-galactosamine 1bj3 
Crystal structure of coagulation factor ix-binding protein (ix-bp) from venom of habu snake with a heterodimer of c- type lectin domains 1buu 
One ho3+ form of rat mannose-binding protein a 1bv4 
Apo-mannose-binding protein-c 1byf 
Structure of tc14; a c-type lectin from the tunicate polyandrocarpa misakiensis 1c3a 
Crystal structure of flavocetin-a from the habu snake venom, a novel cyclic tetramer of c-type lectin-like heterodimers 1dv8 
Crystal structure of the carbohydrate recognition domain of the h1 subunit of the asialoglycoprotein receptor 1e87 
Human cd69 - trigonal form 1e8i 
Human cd69 - tetragonal form 1egg 
Structure of a c-type carbohydrate-recognition domain (crd- 4) from the macrophage mannose receptor 1egi 
Structure of a c-type carbohydrate-recognition domain (crd- 4) from the macrophage mannose receptor 1esl 
Insight into e-selectin(slash)ligand interaction from the crystal structure and mutagenesis of the lec(slash)egf domains 1fif 
N-acetylgalactosamine-selective mutant of mannose-binding protein-a (qpdwg-hdrpy) 1fih 
N-acetylgalactosamine binding mutant of mannose-binding protein a (qpdwg-hdrpy), complex with n-acetylgalactosamine 1fm5 
Crystal structure of human cd69 1fvu 
Crystal structure of botrocetin 1g1q 
Crystal structure of p-selectin lectin/egf domains 1g1r 
Crystal structure of p-selectin lectin/egf domains complexed with slex 1g1s 
P-selectin lectin/egf domains complexed with psgl-1 peptide 1g1t 
Crystal structure of e-selectin lectin/egf domains complexed with slex 1gz2 
Crystal structure of the ovocleidin-17 a major protein of the gallus gallus eggshell calcified layer. 1h8u 
Crystal structure of the eosinophil major basic protein at 1.8a: an atypical lectin with a paradigm shift in specificity 1hq8 
Crystal structure of the murine nk cell-activating receptor nkg2d at 1.95 a 1htn 
Human tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil 1hup 
Human mannose binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled- coil 1hyr 
Crystal structure of human mica in complex with natural killer cell receptor nkg2d 1ijk 
The von willebrand factor mutant (i546v) a1 domain- botrocetin complex 1iod 
Crystal structure of the complex between the coagulation factor x binding protein from snake venom and the gla domain of factor x 1ixx 
Crystal structure of coagulation factors ix/x-binding protein (ix/x-bp) from venom of habu snake with a heterodimer of c-type lectin domains 1j34 
Crystal structure of mg(ii)-and ca(ii)-bound gla domain of factor ix complexed with binding protein 1j35 
Crystal structure of ca(ii)-bound gla domain of factor ix complexed with binding protein 1ja3 
Crystal structure of the murine nk cell inhibitory receptor ly-49i 1jsk 
Crystal structure of murine nk cell ligand rae-1 beta in complex with nkg2d 1jwi 
Crystal structure of bitiscetin, a von willeband factor- dependent platelet aggregation inducer. 1jzn 
Crystal structure of a galactose-specific c-type lectin 1k9i 
Complex of dc-sign and glcnac2man3 1k9j 
Complex of dc-signr and glcnac2man3 1kcg 
Nkg2d in complex with ulbp3 1kg0 
Structure of the epstein-barr virus gp42 protein bound to the mhc class ii receptor hla-dr1 1kmb 
Selectin-like mutant of mannose-binding protein a 1kwt 
Rat mannose binding protein a (native, mpd) 1kwu 
Rat mannose binding protein a complexed with a-me-man 1kwv 
Rat mannose binding protein a complexed with a-me-glcnac 1kww 
Rat mannose protein a complexed with a-me-fuc. 1kwx 
Rat mannose protein a complexed with b-me-fuc. 1kwy 
Rat mannose protein a complexed with man-a13-man. 1kwz 
Rat mannose protein a (h189v) complexed with man-a13-man 1kx0 
Rat mannose protein a (h189v i207v) complexed with man-a13- man 1kx1 
Rat mannose protein a complexed with man6-glcnac2-asn 1kza 
Complex of mbp-c and man-a13-man 1kzb 
Complex of mbp-c and trimannosyl core 1kzc 
Complex of mbp-c and high-affinity linear trimannose 1kzd 
Complex of mbp-c and glcnac-terminated core 1kze 
Complex of mbp-c and bivalent man-terminated glycopeptide 1lit 
Human lithostathine 1mpu 
Crystal structure of the free human nkg2d immunoreceptor 1msb 
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by mad phasing 1muq 
X-ray crystal structure of rattlesnake venom complexed with thiodigalactoside 1oz7 
Crystal structure of echicetin from the venom of indian saw- scaled viper (echis carinatus) at 2.4 resolution 1p1z 
X-ray crystal structure of the lectin-like natural killer cell receptor ly-49c bound to its mhc class i ligand h-2kb 1p4l 
Crystal structure of nk receptor ly49c mutant with its mhc class i ligand h-2kb 1pw9 
High resolution crystal structure of an active recombinant fragment of human lung surfactant protein d 1pwb 
High resolution crystal structure of an active recombinant fragment of human lung surfactant protein d with maltose 1qdd 
Crystal structure of human lithostathine to 1.3 a resolution 1qo3 
Complex between nk cell receptor ly49a and its mhc class i ligand h-2dd 1r13 
Carbohydrate recognition and neck domains of surfactant protein a (sp-a) 1r14 
Carbohydrate recognition and neck domains of surfactant protein a (sp-a) containing samarium 1rdi 
Mannose-binding protein, subtilisin digest fragment complex with alpha-methyl-l-fucopyranoside 1rdj 
Mannose-binding protein, subtilisin digest fragment complex with beta-methyl-l-fucopyranoside 1rdk 
Mannose-binding protein, subtilisin digest fragment complex with d-galactose 1rdl 
Mannose-binding protein, subtilisin digest fragment complex with alpha-methyl-d-mannopyranoside (0.2 m) 1rdm 
Mannose-binding protein, subtilisin digest fragment complex with alpha-methyl-d-mannopyranoside (1.3 m) 1rdn 
Mannose-binding protein, subtilisin digest fragment complex with alpha-methyl-d-n-acetylglucosaminide 1rdo 
Mannose-binding protein, subtilisin digest fragment 1rjh 
Structure of the calcium free form of the c-type lectin- like domain of tetranectin 1rtm 
Trimeric structure of a c-type mannose-binding protein 1sb2 
High resolution structure determination of rhodocetin 1sl4 
Crystal structure of dc-sign carbohydrate recognition domain complexed with man4 1sl5 
Crystal structure of dc-sign carbohydrate recognition domain complexed with lnfp iii (dextra l504). 1sl6 
Crystal structure of a fragment of dc-signr (containg the carbohydrate recognition domain and two repeats of the neck) complexed with lewis-x. 1t8c 
Structure of the c-type lectin domain of cd23 1t8d 
Structure of the c-type lectin domain of cd23 1tdq 
Structural basis for the interactions between tenascins and the c-type lectin domains from lecticans: evidence for a cross-linking role for tenascins 1tlg 
Structure of a tunicate c-type lectin complexed with d- galactose 1tn3 
The c-type lectin carbohydrate recognition domain of human tetranectin 1u0n 
The ternary von willebrand factor a1-glycoprotein ibalpha- botrocetin complex 1u0o 
The mouse von willebrand factor a1-botrocetin complex 1uex 
Crystal structure of von willebrand factor a1 domain complexed with snake venom bitiscetin 1ukm 
Crystal structure of ems16, an antagonist of collagen receptor integrin alpha2beta1 (gpia/iia) 1umr 
Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of crotalus durissus terrificus 1uos 
The crystal structure of the snake venom toxin convulxin 1uv0 
Pancreatitis-associated protein 1 from human 1v4l 
Crystal structure of a platelet agglutination factor isolated from the venom of taiwan habu (trimeresurus mucrosquamatus) 1v7p 
Structure of ems16-alpha2-i domain complex 1wk1 
Solution structure of lectin c-type domain derived from a hypothetical protein from c. elegans 1wmy 
Crystal structure of c-type lectin cel-i from cucumaria echinata 1wmz 
Crystal structure of c-type lectin cel-i complexed with n- acetyl-d-galactosamine 1wt9 
Crystal structure of aa-x-bp-i, a snake venom protein with the activity of binding to coagulation factor x from agkistrodon acutus 1x2t 
Crystal structure of habu ix-bp at ph 6.5 1x2w 
Crystal structure of apo-habu ix-bp at ph 4.6 1xar 
Crystal structure of a fragment of dc-signr (containing the carbohydrate recognition domain and two repeats of the neck). 1xph 
Structure of dc-signr and a portion of repeat domain 8 1y17 
Crystal structure of aa-x-bp-ii, a snake venom protein with the activity of binding to coagulation factor x from agkistrodon acutus 1ypo 
Human oxidized low density lipoprotein receptor lox-1 p3 1 space group 1ypq 
Human oxidized low density lipoprotein receptor lox-1 dioxane complex 1ypu 
Human oxidized low density lipoprotein receptor lox-1 c2 space group 1ytt 
Yb substituted subtilisin fragment of mannose binding protein-a (sub-mbp-a), mad structure at 110k 1yxj 
Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (lox-1) at low ph 1yxk 
Crystal structure of human lectin-like oxidized low-density lipoprotein receptor 1 (lox-1) disulfide-linked dimer 2afp 
The solution structure of type ii antifreeze protein reveals a new member of the lectin family 2b6b 
Cryo em structure of dengue complexed with crd of dc-sign 2bpd 
Structure of murine dectin-1 2bpe 
Structure of murine dectin-1 2bph 
Structure of murine dectin-1 2brs 
Embp heparin complex 2c6u 
Crystal structure of human clec-2 (clec1b) 2cl8 
Dectin-1 in complex with beta-glucan 2e3x 
Crystal structure of russell's viper venom metalloproteinase 2ggu 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with maltotriose 2ggx 
Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein d in complex with p-nitrophenyl maltoside 2go0 
Nmr solution structure of human pancreatitis-associated protein 2h2r 
Crystal structure of the human cd23 lectin domain, apo form 2h2t 
Cd23 lectin domain, calcium 2+-bound 2it5 
Crystal structure of dcsign-crd with man6 2it6 
Crystal structure of dcsign-crd with man2 2kmb 
Complex of 3'-neuac-lewis-x with a selectin-like mutant of mannose-binding protein a 2msb 
Structure of a c-type mannose-binding protein complexed with an oligosaccharide 2orj 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with n-acetyl mannosamine 2ork 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with inositol-1-phosphate 2os9 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with myoinositol 2ox8 
Human scavenger receptor c-type lectin carbohydrate- recognition domain. 2ox9 
Mouse scavenger receptor c-type lectin carbohydrate- recognition domain. 2py2 
Structure of herring type ii antifreeze protein 2ria 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with d-glycero-d-manno-heptose 2rib 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with l-glycero-d-manno-heptose 2ric 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with l-glycero-d-manno-heptopyranosyl-(1-3)-l-glycero-d- manno-heptopyranose 2rid 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with allyl 7-o-carbamoyl-l-glycero-d-manno- heptopyranoside 2rie 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with 2-deoxy-l-glycero-d-manno-heptose 2vrp 
Structure of rhodocytin 2vuv 
Crystal structure of codakine at 1.3a resolution 2vuz 
Crystal structure of codakine in complex with biantennary nonasaccharide at 1.7a resolution 2zib 
Crystal structure analysis of calcium-independent type ii antifreeze protein 3bbs 
The carbohydrate recognition domain of langerin reveals high structural similarity with the one of dc-sign but an additional, calcium-independent sugar-binding site 3bc6 
The carbohydrate recognition domain of langerin reveals high structural similarity with the one of dc-sign but an additional, calcium-independent sugar-binding site 3bc7 
The carbohydrate recognition domain of langerin reveals high structural similarity with the one of dc-sign but an additional, calcium-independent sugar-binding site 3bdw 
Human cd94/nkg2a 3bx4 
Crystal structure of the snake venom toxin aggretin 3c22 
Crystal structure of the carbohydrate recognition domain of human langerin 3c8j 
The crystal structure of natural killer cell receptor ly49c 3c8k 
The crystal structure of ly49c bound to h-2kb 3cad 
Crystal structure of natural killer cell receptor, ly49g 3cck 
Human cd69 3cdg 
Human cd94/nkg2a in complex with hla-e 3cfw 
L-selectin lectin and egf domains 3cii 
Structure of nkg2a/cd94 bound to hla-e 3dbz 
Human surfactant protein d 3fd4 
Crystal structure of epstein-barr virus gp42 protein 3ff7 
Structure of nk cell receptor klrg1 bound to e-cadherin 3ff8 
Structure of nk cell receptor klrg1 bound to e-cadherin 3ff9 
Structure of nk cell receptor klrg1 3g81 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha methyl mannoside 3g83 
Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha 1,2 dimannose. 3g84 
Crystal structure of the trimeric neck and carbohydrate recognition domain of r343v mutant of human surfactant protein d in complex with alpha 1,2 dimannose. 3g8k 
Crystal structure of murine natural killer cell receptor, ly49l4 3g8l 
Crystal structure of murine natural killer cell receptor, ly49l4 3ikn 
Crystal structure of galactose bound trimeric human lung surfactant protein d 3ikp 
Crystal structure of inositol phosphate bound trimeric human lung surfactant protein d 3ikq 
Crystal structure of alpha 1-2 mannobiose bound trimeric human lung surfactant protein d 3ikr 
Crystal structure of alpha 1-4 mannobiose bound trimeric human lung surfactant protein d 3kmb 
Complex of 3'-sulfo-lewis-x with a selectin-like mutant of mannose-binding protein a 4kmb 
Complex of 4'-sulfo-lewis-x with a selectin-like mutant of mannose-binding protein a - Links (links to other resources describing this domain)
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BLOCKS C_TYPE_LECTIN_1 PFAM lectin_c INTERPRO IPR001304 PROSITE CLECT_DOMAIN