SMART: CYCLIN domain annotation

CYCLIN domain present in cyclins, TFIIB and Retinoblastoma

SMART accession number:	SM00385
Description:	A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.
Interpro abstract (IPR013763):	This cyclin-like domain is found in cyclins, but it is also found as the core domain in transcription factor IIB (TFIIB) [ (PUBMED:7675079) ] and in the retinoblastoma tumour suppressor [ (PUBMED:17974914) ]. It consists of a duplication of a fold consisting of 5 helices, one of them surrounded by the others.
Family alignment:	View or

There are 61335 CYCLIN domains in 41443 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing CYCLIN domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CYCLIN domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing CYCLIN domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Cellular role: transcription
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Endicott JA, Noble ME
- Structural principles in cell-cycle control: beyond the CDKs.
- Structure. 1998; 6: 535-41
- Display abstract
- Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. Clues to the atomic mechanisms involved are offered by the structure of the two pocket regions of Rb in complex with a short peptide from a viral oncoprotein. Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control.
- Lee JO, Russo AA, Pavletich NP
- Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7.
- Nature. 1998; 391: 859-65
- Display abstract
- The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.
- Kim HY, Cho Y
- Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box.
- Nat Struct Biol. 1997; 4: 390-5
- Display abstract
- The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
- Noble ME, Endicott JA, Brown NR, Johnson LN
- The cyclin box fold: protein recognition in cell-cycle and transcription control.
- Trends Biochem Sci. 1997; 22: 482-7
- Display abstract
- Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
- Bagby S, Kim S, Maldonado E, Tong KI, Reinberg D, Ikura M
- Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.
- Cell. 1995; 82: 857-67
- Display abstract
- TFIIB is an essential component of the machinery that transcribes protein-coding genes. The three-dimensional structure of the human TFIIB core domain (TFIIBc) has been determined using multidimensional heteronuclear magnetic resonance spectroscopy. The molecule consists of two direct repeats that adopt similar alpha-helical folds, conferring pseudo-twofold symmetry. An extensive, central basic surface including an amphipathic alpha helix is critical to the function of TFIIB as a bridge between the TBP-promoter complex and RNA polymerase II and associated general and regulatory transcription factors. Similarities between the TFIIBc and cyclin A folds indicate that elements of the eukaryotic cell cycle control apparatus evolved from more fundamental transcriptional control components, demonstrating a link between the transcription and cell cycle molecular machineries.
- Gibson TJ, Thompson JD, Blocker A, Kouzarides T
- Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.
- Nucleic Acids Res. 1994; 22: 946-52
- Display abstract
- Cyclins, TFIIB and RB play major roles in cell cycle and/or gene regulation. Earlier work has suggested common ancestry for the TFIIB repeats and RB pocket B which share 20% sequence identity. We now report that database searches with profiles based on a multiple alignment of cyclin core regions (the 'cyclin box') detect the TFIIB repeats with equivalent scores to divergent cyclins. Several features of the sequences support the notion of common ancestry: e.g. cyclins A/B, C and D share approximately 20-30% identity but each have approximately 15-20% identity with vertebrate TFIIB, showing that conserved cyclin features underlie the match. These results suggest the presence of a domain superfamily, which we term the TR domain, in nuclear regulatory proteins belonging to the TFIIB, cyclin and RB families, that has been duplicated many times during eukaryotic evolution. The TR domain appears to function in protein-protein interactions.
Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the CYCLIN domain.

Protein Disease

Retinoblastoma-associated protein (P06400) (SMART) OMIM:180200: Retinoblastoma ; Osteosarcoma
OMIM:259500: Bladder cancer
OMIM:109800: Pinealoma with bilateral retinoblastoma
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

Protein	Disease
Retinoblastoma-associated protein (P06400) (SMART)	OMIM:180200: Retinoblastoma ; Osteosarcoma OMIM:259500: Bladder cancer OMIM:109800: Pinealoma with bilateral retinoblastoma

3D Structures of CYCLIN domains in PDB

PDB code	Main view	Title
1ais		TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
1bu2		X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI
1c9b		CRYSTAL STRUCTURE OF A HUMAN TBP CORE DOMAIN-HUMAN TFIIB CORE DOMAIN COMPLEX BOUND TO AN EXTENDED, MODIFIED ADENOVIRAL MAJOR LATE PROMOTER (ADMLP)
1d3u		TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
1e9h		Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound
1f5q		CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2
1fin		CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
1fvv		THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
1g3n		STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX
1gh6		RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
1gux		RB POCKET BOUND TO E7 LXCXE MOTIF
1gy3		pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate
1h1p		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058
1h1q		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094
1h1r		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086
1h1s		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102
1h24		CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
1h25		CDK2/CyclinA in complex with an 11-residue recruitment peptide from E2F
1h26		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
1h27		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
1h28		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
1jkw		STRUCTURE OF CYCLIN MCS2
1jow		Crystal structure of a complex of human CDK6 and a viral cyclin
1jst		PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
1jsu		P27(KIP1)/CYCLIN A/CDK2 COMPLEX
1kxu		CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
1n4m		Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
1o9k		Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
1ogu		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR
1oi9		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1oiu		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1oiy		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
1okv		Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2
1okw		Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2
1ol1		Cyclin A binding groove inhibitor H-Cit-Cit-Leu-Ile-(p-F-Phe)-NH2
1ol2		Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Asn-(p-F-Phe)-NH2
1p5e		The strucure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
1pkd		THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
1qmz		PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
1tfb		NMR STUDIES OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIB: DYNAMICS AND INTERACTION WITH VP16 ACTIVATION DOMAIN, 20 STRUCTURES
1urc		Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly
1vin		BOVINE CYCLIN A3
1vol		TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX
1vyw		Structure of CDK2/Cyclin A with PNU-292137
1w98		The structural basis of CDK2 activation by cyclin E
1xo2		Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
1zp2		Structure of the Mediator subunit cyclin C
2b9r		Crystal Structure of Human Cyclin B1
2bkz		STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611
2bpm		STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529
2c4g		STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
2c5n		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5o		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5v		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c5x		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
2c6t		Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
2cch		The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
2cci		Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
2cjm		Mechanism of CDK inhibition by active site phosphorylation: CDK2 Y15p T160p in complex with cyclin A structure
2euf		X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
2f2c		X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol
2g9x		Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
2i40		Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor
2i53		Crystal structure of Cyclin K
2ivx		Crystal structure of human cyclin T2 at 1.8 A resolution (CASP target)
2iw6		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
2iw8		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
2iw9		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
2jgz		Crystal structure of phospho-CDK2 in complex with Cyclin B
2phg		Model for VP16 binding to TFIIB
2pk2		Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat
2r7g		Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
2uue		REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
2uzb		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzd		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uze		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2uzl		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
2v22		REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
2w2h		Structural basis of transcription activation by the Cyclin T1-Tat-TAR RNA complex from EIAV
2w96		Crystal Structure of CDK4 in complex with a D-type cyclin
2w99		Crystal Structure of CDK4 in complex with a D-type cyclin
2w9f		Crystal Structure of CDK4 in complex with a D-type cyclin
2w9z		Crystal Structure of CDK4 in complex with a D-type cyclin
2wev		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2wfy		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2whb		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
2wih		STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125
2wip		STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID
2wma		Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
2wmb		Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
2wpa		Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing
2wxv		Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor
2x1n		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
3bht		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3
3bhu		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
3bhv		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B
3blh		Crystal Structure of Human CDK9/cyclinT1
3blq		Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP
3blr		Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
3ddp		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
3ddq		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
3dog		Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1
3eid		CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
3ej1		CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
3eoc		Cdk2/CyclinA complexed with a imidazo triazin-2-amine
3f5x		CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site
3g33		Crystal structure of CDK4/cyclin D3
3k7a		Crystal Structure of an RNA polymerase II-TFIIB complex
3lq5		Structure of CDK9/CyclinT in complex with S-CR8
3mi9		Crystal structure of HIV-1 Tat complexed with human P-TEFb
3mia		Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb
3my1		Structure of CDK9/cyclinT1 in complex with DRB
3my5		CDk2/cyclinA in complex with DRB
3pom		Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain
3qhr		Structure of a pCDK2/CyclinA transition-state mimic
3qhw		Structure of a pCDK2/CyclinA transition-state mimic
3rgf		Crystal Structure of human CDK8/CycC
3tn8		CDK9/cyclin T in complex with CAN508
3tnh		CDK9/cyclin T in complex with CAN508
3tni		structure of CDK9/cyclin T F241L
3tnw		Structure of CDK2/cyclin A in complex with CAN508
4bbr		Structure of RNA polymerase II-TFIIB complex
4bbs		Structure of an initially transcribing RNA polymerase II-TFIIB complex
4bcf		Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcg		Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bch		Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bci		Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcj		Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bck		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcm		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcn		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bco		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcp		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4bcq		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
4cfm		4CFM
4cfn		Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
4cfu		4CFU
4cfv		4CFV
4cfw		Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
4cfx		4CFX
4crl		4CRL
4cxa		Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP
4ec8		Structure of full length CDK9 in complex with cyclinT and DRB
4ec9		Crystal structure of full-length cdk9 in complex with cyclin t
4elj		Crystal structure of the inactive retinoblastoma protein phosphorylated at T373
4ell		Structure of the inactive retinoblastoma protein pocket domain
4eoi		Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoj		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP
4eok		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
4eol		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306
4eom		Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP
4eon		Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoo		Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP
4eop		Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
4eoq		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP
4eor		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102
4eos		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
4f6s		Crystal structure of human CDK8/CYCC in complex with compound 7 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea)
4f6u		Crystal structure of human CDK8/CYCC in complex with compound 5 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea)
4f6w		Crystal structure of human CDK8/CYCC in complex with compound 1 (N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide)
4f70		Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea)
4f7j		Crystal structure of human CDK8/CYCC in complex with compound 3 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(2-hydroxyethyl)urea)
4f7l		Crystal structure of human CDK8/CYCC in complex with compound 2 (tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate)
4f7n		Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea)
4f7s		Crystal structure of human CDK8/CYCC in the DMG-in conformation
4fx3		Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
4g6l		Crystal structure of human CDK8/CYCC in the DMG-in conformation
4i3z		Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
4ii5		Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
4imy		The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
4nst		Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
4ogr		crystal structure of P-TEFb complex with AFF4 and Tat
4or5		Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
4roc		4ROC
4rod		4ROD
4roe		4ROE
4tth		4TTH
4un0		4UN0
4v1n		4V1N
4v1o		4V1O
4y72		4Y72
4yc3		4YC3
4yoo		4YOO
4yos		4YOS
4yoz		4YOZ
5acb		5ACB
5bnj		5BNJ
5cei		5CEI
5cyi		5CYI
5efq		5EFQ
5fgk		5FGK
5fmf		5FMF
5fyw		5FYW
5fz5		5FZ5
5hbe		5HBE
5hbh		5HBH
5hbj		5HBJ
5hnb		5HNB
5hq0		5HQ0
5hvy		5HVY
5i5z		5I5Z
5if1		5IF1
5iy6		5IY6
5iy7		5IY7
5iy8		5IY8
5iy9		5IY9
5iya		5IYA
5iyb		5IYB
5iyc		5IYC
5iyd		5IYD
5l1z		5L1Z
5l2w		5L2W
5sva		5SVA

Links (links to other resources describing this domain)
PROSITE CYCLINS
INTERPRO IPR013763
PFAM cyclin

PROSITE	CYCLINS
INTERPRO	IPR013763
PFAM	cyclin

CYCLIN

Taxonomic distribution of proteins containing CYCLIN domain.

3D Structures of CYCLIN domains in PDB