• Links (links to other resources describing this domain)
  • Cir_N

    N-terminal domain of CBF1 interacting co-repressor CIR
    Cir_N
    SMART accession number:SM01083
    Description: This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex (PUBMED:9874765).
    Interpro abstract (IPR019339):

    This entry represents a 45 residue conserved domain that is found at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors).

    CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [(PUBMED:9874765)]. It may also modulate splice site selection during alternative splicing of pre-mRNAs.

    Family alignment:
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    There are 795 Cir_N domains in 795 proteins in SMART's nrdb database.

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