Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Copper-fist

SMART accession number:	SM01090
Description:	Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist. It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1201 Copper-fist domains in 1201 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Copper-fist domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Copper-fist domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Copper-fist domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: transcription
  Binding / catalysis: DNA binding

• Structure (3D structures containing this domain)

• 3D Structures of Copper-fist domains in PDB

  PDB code	Main view	Title
  1co4		SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS

• Links (links to other resources describing this domain)

• PFAM	Copper-fist

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