|SMART accession number:||SM01090
||Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist. It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.|
There are 364 Copper-fist domains in 358 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)