Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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DHHA2

SMART accession number:	SM01131
Description:	This domain is often found adjacent to the DHH domain PF01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members ((PUBMED:9478130)). The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.
Interpro abstract (IPR004097):	This domain is called DHHA2 since it is often associated with the DHH domain ( IPR001667 ) and is diagnostic of DHH subfamily 2 members [ (PUBMED:9478130) ]. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus. It is present in inorganic pyrophosphatases and in exopolyphosphatase of Saccharomyces cerevisiae.
GO component:	cytoplasm (GO:0005737)
GO function:	pyrophosphatase activity (GO:0016462)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 6950 DHHA2 domains in 6949 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing DHHA2 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DHHA2 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing DHHA2 domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Aravind L, Koonin EV
  • A novel family of predicted phosphoesterases includes Drosophila prune proteinand bacterial RecJ exonuclease.
  • Trends Biochem Sci. 1998; 23: 17-9
• Structure (3D structures containing this domain)

• 3D Structures of DHHA2 domains in PDB

  PDB code	Main view	Title
  1i74		STREPTOCOCCUS MUTANS INORGANIC PYROPHOSPHATASE
  1k20		Inorganic Pyrophosphatase (family II) from Streptococcus gordonii at 1.5 A resolution
  1k23		Inorganic Pyrophosphatase (Family II) from Bacillus subtilis
  1wpm		Structure of Bacillus subtilis inorganic pyrophosphatase
  1wpp		Structure of Streptococcus gordonii inorganic pyrophosphatase
  2eb0		Crystal structure of Methanococcus jannaschii putative family II inorganic pyrophosphatase
  2enx		Structure of the family II inorganic pyrophosphatase from Streptococcus agalactiae at 2.8 resolution
  2haw		Crystal structure of family II Inorganic pyrophosphatase in complex with PNP
  2iw4		CRYSTAL STRUCTURE OF BASILLUS SUBTILIS FAMILY II INORGANIC PYROPHOSPHATASE MUTANT, H98Q, IN COMPLEX WITH PNP
  2qb6		Saccharomyces cerevisiae cytosolic exopolyphosphatase, sulfate complex
  2qb7		Saccharomyces cerevisiae cytosolic exopolyphosphatase, phosphate complex
  2qb8		Saccharomyces cerevisiae cytosolic exopolyphosphatase, ATP complex
  4rpa		4RPA

• Links (links to other resources describing this domain)

• INTERPRO	IPR004097
  PFAM	DHHA2

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