DKCLDDKCLD (NUC011) domain
|SMART accession number:||SM01136|
|Description:||This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins ((PUBMED:15112237)).|
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- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing DKCLD domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DKCLD domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing DKCLD domain in the selected taxonomic class.
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Staub E, Fiziev P, Rosenthal A, Hinzmann B
- Insights into the evolution of the nucleolus by an analysis of its protein domainrepertoire.
- Bioessays. 2004; 26: 567-81
- Display abstract
Recently, the first investigation of nucleoli using mass spectrometry led to the identification of 271 proteins. This represents a rich resource for acomprehensive investigation of nucleolus evolution. We applied a protocol for theidentification of known and novel conserved protein domains of the nucleolus,resulting in the identification of 115 known and 91 novel domain profiles. Thephyletic distribution of nucleolar protein domains in a collection of completeproteomes of selected organisms from all domains of life confirms thearchaebacterial origin of the core machinery for ribosome maturation andassembly, but also reveals substantial eubacterial and eukaryotic contributionsto nucleolus evolution. We predict that, in different phases of nucleolusevolution, protein domains with different biochemical functions were recruited tothe nucleolus. We suggest a model for the late and continuous evolution of thenucleolus in early eukaryotes and argue against an endosymbiotic origin of thenucleolus and the nucleus. Supplementary material for this article can be foundon the BioEssays website athttp://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html.
- Structure (3D structures containing this domain)
3D Structures of DKCLD domains in PDB
PDB code Main view Title 1sgv STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB) 2apo Crystal Structure of the Methanococcus jannaschii Cbf5 Nop10 Complex 2aus Crystal structure of the archaeal box H/ACA sRNP Nop10-Cbf5 complex 2ey4 Crystal Structure of a Cbf5-Nop10-Gar1 Complex 2hvy Crystal structure of an H/ACA box RNP from Pyrococcus furiosus 2rfk Substrate RNA Positioning in the Archaeal H/ACA Ribonucleoprotein Complex 3hax Crystal structure of a substrate-bound Gar1-minus H/ACA RNP from Pyrococcus furiosus 3hay Crystal structure of a substrate-bound full H/ACA RNP from Pyrococcus furiosus 3hjw Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA 3hjy Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA 3lwo Structure of H/ACA RNP bound to a substrate RNA containing 5BrU 3lwp Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU 3lwq Structure of H/ACA RNP bound to a substrate RNA containing 3MU 3lwr Structure of H/ACA RNP bound to a substrate RNA containing 4SU 3lwv Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine 3mqk Cbf5-Nop10-Gar1 complex binding with 17mer RNA containing ACA trinucleotide 3u28 Crystal structure of a Cbf5-Nop10-Gar1 complex from Saccharomyces cerevisiae 3uai Structure of the Shq1-Cbf5-Nop10-Gar1 complex from Saccharomyces cerevisiae 3zv0 Structure of the SHQ1P-CBF5P complex
- Links (links to other resources describing this domain)