SMART: DKCLD domain annotation

DKCLD DKCLD (NUC011) domain

SMART accession number:	SM01136
Description:	This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins ((PUBMED:15112237)).
Family alignment:	View or

There are 299 DKCLD domains in 299 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with DKCLD domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Staub E, Fiziev P, Rosenthal A, Hinzmann B
- Insights into the evolution of the nucleolus by an analysis of its protein domainrepertoire.
- Bioessays. 2004; 26: 567-81
- Display abstract
- Recently, the first investigation of nucleoli using mass spectrometry led to the identification of 271 proteins. This represents a rich resource for acomprehensive investigation of nucleolus evolution. We applied a protocol for theidentification of known and novel conserved protein domains of the nucleolus,resulting in the identification of 115 known and 91 novel domain profiles. Thephyletic distribution of nucleolar protein domains in a collection of completeproteomes of selected organisms from all domains of life confirms thearchaebacterial origin of the core machinery for ribosome maturation andassembly, but also reveals substantial eubacterial and eukaryotic contributionsto nucleolus evolution. We predict that, in different phases of nucleolusevolution, protein domains with different biochemical functions were recruited tothe nucleolus. We suggest a model for the late and continuous evolution of thenucleolus in early eukaryotes and argue against an endosymbiotic origin of thenucleolus and the nucleus. Supplementary material for this article can be foundon the BioEssays website athttp://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html.
Structure (3D structures containing this domain)

Links (links to other resources describing this domain)
PFAM DKCLD

PDB code	Main view	Title
1sgv		Structure of trna psi55 pseudouridine synthase (trub)
2apo		Crystal structure of the methanococcus jannaschii cbf5 nop10 complex
2aus		Crystal structure of the archaeal box h/aca srnp nop10-cbf5 complex
2ey4		Crystal structure of a cbf5-nop10-gar1 complex
2hvy		Crystal structure of an h/aca box rnp from pyrococcus furiosus
2rfk		Substrate rna positioning in the archaeal h/aca ribonucleoprotein complex
3hax		Crystal structure of a substrate-bound gar1-minus h/aca rnp from pyrococcus furiosus
3hay		Crystal structure of a substrate-bound full h/aca rnp from pyrococcus furiosus
3hjw		Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate rna
3hjy		Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate rna

DKCLD

3D Structures of DKCLD domains in PDB