Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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DMAP_binding DMAP1-binding Domain

SMART accession number:	SM01137
Description:	This domain binds DMAP1, a transcriptional co-repressor.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 219 DMAP_binding domains in 219 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a DMAP_binding domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with DMAP_binding domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: transcription
  Binding / catalysis: Binds DMAP1, a transcriptional co-repressor.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Rountree MR, Bachman KE, Baylin SB
  • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replicationfoci.
  • Nat Genet. 2000; 25: 269-77
  • Display abstract

  • DNA methylation can contribute to transcriptional silencing through severaltranscriptionally repressive complexes, which include methyl-CpG binding domainproteins (MBDs) and histone deacetylases (HDACs). We show here that the chiefenzyme that maintains mammalian DNA methylation, DNMT1, can also establish arepressive transcription complex. The non-catalytic amino terminus of DNMT1 bindsto HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediatetranscriptional repression. DMAP1 has intrinsic transcription repressiveactivity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targetedto replication foci through interaction with the far N terminus of DNMT1throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase,providing a platform for how histones may become deacetylated in heterochromatin following replication. Thus, DNMT1 not only maintains DNA methylation, but alsomay directly target, in a heritable manner, transcriptionally repressivechromatin to the genome during DNA replication.

• Links (links to other resources describing this domain)

• PFAM	DMAP_binding

Send comments to Ivica Letunic