This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (PDB:3iuz).
Family alignment:
There are 428
DUF1338 domains in 428 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a DUF1338 domain in a specific node, click on it.
This tree shows only several representative species. The complete taxonomic breakdown of all proteins with DUF1338 domain is also avaliable.
Crystal structure of uncharacterized protein ydcj (sf1787) from shigella flexneri which includes domain duf1338. northeast structural genomics consortium target sfr276