DUF1693

Domain of unknown function (DUF1693)
DUF1693
SMART accession number:SM01153
Description: This family contains many hypothetical proteins. It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily.
Interpro abstract (IPR012937):

The function of FAM46 family is not clear. FAM46 family members contain a NTase (nucleotidyltransferase) domain, some members possess additional C-terminal PAP/OAS1 substrate binding domain [(PUBMED:19833706)]. They have different functions in many tissues at various stages of development. Human FAM46A is a SMAD signalling pathway related protein, where SMADs are intercellular effectors of transforming growth factor-beta (TGF-beta) [(PUBMED:19833706)]. Human FAM46C seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon [(PUBMED:17803723)].

Family alignment:
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There are 1596 DUF1693 domains in 1586 proteins in SMART's nrdb database.

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