DUF1716Eukaryotic domain of unknown function (DUF1716) |
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| SMART accession number: | SM01156
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| Description: |
This domain is found in eukaryotic proteins. A human nuclear protein with this domain (Q8WYA6) is thought to have a role in apoptosis [(PUBMED:12659813)]. |
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| Family alignment: |
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There are 146
DUF1716 domains in 146 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Jabbour L, Welter JF, Kollar J, Hering TM
- Sequence, gene structure, and expression pattern of CTNNBL1, a minor-classintron-containing gene--evidence for a role in apoptosis.
- Genomics. 2003; 81: 292-303
- Display abstract
We have identified and characterized a cDNA designated CTNNBL1 (catenin(cadherin-associated protein), beta-like 1) coding for a protein of 563 aminoacids having predicted structural homology to beta-catenin and other armadillo(arm) family proteins. CTNNBL1 is expressed in multiple human tissues, and itssequence is conserved across widely divergent species. The human CTNNBL1 gene on chromosome 20q11.2 contains 16 exons spanning > 178 kb. Intron 4 is a minor-classintron bearing AT at the 5' splice site and AC at the 3' splice site. An acidicdomain, as well as a putative bipartite nuclear localization signal, a nuclearexport signal, a leucine-isoleucine zipper, and phosphorylation motifs arepresent in the protein sequence. Transient expression of CTNNBL1 in CHO cellsresults in localization to the nucleus and apoptosis. The rate of cell death was higher when cells were transfected with a carboxy-terminal fragment of CTNNBL1,suggesting that the apoptosis-inducing activity is a function of this region.
- Links (links to other resources describing this domain)
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