EFhEF-hand, calcium binding motif
|SMART accession number:||SM00054|
|Description:||EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.|
|Interpro abstract (IPR002048):||Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).|
|GO function:||calcium ion binding (GO:0005509)|
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- Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a EFh domain in a specific node, click on it.
This tree shows only several representative species. The complete taxonomic breakdown of all proteins with EFh domain is also avaliable.
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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
- Cellular role (predicted cellular role)
Binding / catalysis: Ca2+-binding
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Kretsinger RH
- EF-hands embrace.
- Nat Struct Biol. 1997; 4: 514-6
- Ikura M
- Calcium binding and conformational response in EF-hand proteins.
- Trends Biochem Sci. 1996; 21: 14-7
- Display abstract
EF-hand proteins undergo conformational changes upon binding of Ca2+. This event is a crucial step in many Ca2+-dependent cellular processes. Recent advances in the three-dimensional structural analysis of various EF-hand proteins have led to new insights into the structure and functional relationship of this large family of Ca2+-binding proteins.
- Schafer BW, Heizmann CW
- The S100 family of EF-hand calcium-binding proteins: functions and pathology.
- Trends Biochem Sci. 1996; 21: 134-40
- Display abstract
Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.
- Akke M, Forsen S, Chazin WJ
- Solution structure of (Cd2+)1-calbindin D9k reveals details of the stepwise structural changes along the Apo-->(Ca2+)II1-->(Ca2+)I,II2 binding pathway.
- J Mol Biol. 1995; 252: 102-21
- Display abstract
The three-dimensional solution structure of (Cd2+)1-calbindin D9k has been determined by distance geometry, restrained molecular dynamics and relaxation matrix calculations using experimental constraints obtained from two-dimensional 1H and 15N-1H NMR spectroscopy. The final input data consisted of 1055 NOE distance constraints and 71 dihedral angle constraints, corresponding to 15 constraints per residue on average. The resulting ensemble of 24 structures has no distance or dihedral angle constraints consistently violated by more than 0.07 A and 1.8 degrees, respectively. The structure is characteristic of an EF-hand protein, with two helix-loop-helix calcium binding motifs joined by a flexible linker, and a short anti-parallel beta-type interaction between the two ion-binding sites. The four helices are well defined with a root mean square deviation from the mean coordinates of 0.35 A for the backbone atoms. The structure of the half-saturated cadmium state was compared with the previously determined solution structures of the apo and fully calcium saturated calbindin D9k. The comparisons were aided by introducing the ensemble averaged distance difference matrix as a tool for analyzing differences between two ensembles of structures. Detailed analyses of differences between the three states in backbone and side-chain dihedral angles, hydrogen bonds, interatomic distances, and packing of the hydrophobic core reveal the reorganization of the protein that occurs upon ion binding. Overall, it was found that (Cd2+)1-calbindin D9k, representing the half-saturated calcium state with an ion in site II, is structurally more similar to the fully calcium-saturated state than the apo state. Thus, for the binding sequence apo-->(Ca2+)II1-->(Ca2+)I,II2, the structural changes occurring upon ion binding are most pronounced for the first binding step, an observation that bears significantly on the molecular basis for cooperative calcium binding in calbindin D9k.
- Kawasaki H, Kretsinger RH
- Calcium-binding proteins 1: EF-hands.
- Protein Profile. 1995; 2: 297-490
- Potts BC et al.
- The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins.
- Nat Struct Biol. 1995; 2: 790-6
- Display abstract
The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol. This structure reveals a symmetric homodimeric fold that is unique among calcium-binding proteins. Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins.
- Skelton NJ, Kordel J, Chazin WJ
- Determination of the solution structure of Apo calbindin D9k by NMR spectroscopy.
- J Mol Biol. 1995; 249: 441-62
- Display abstract
The three-dimensional structure of apo calbindin D9k has been determined using constraints generated from nuclear magnetic resonance spectroscopy. The family of solution structures was calculated using a combination of distance geometry, restrained molecular dynamics, and hybrid relaxation matrix analysis of the nuclear Overhauser effect (NOE) cross-peak intensities. Errors and inconsistencies in the input constraints were identified using complete relaxation matrix analyses based on the results of preliminary structure calculations. The final input data consisted of 994 NOE distance constraints and 122 dihedral constraints, aided by the stereospecific assignment of the resonances from 21 beta-methylene groups and seven isopropyl groups of leucine and valine residues. The resulting family of 33 structures contain no violation of the distance constraints greater than 0.17 A or of the dihedral angle constraints greater than 10 degrees. The structures consist of a well-defined, antiparallel four-helix bundle, with a short anti-parallel beta-interaction between the two unoccupied calcium-binding loops. The root-mean-square deviation from the mean structure of the backbone heavy-atoms for the well-defined helical residues is 0.55 A. The remainder of the ion-binding loops, the linker loop connecting the two sub-domains of the protein, and the N and C termini exhibit considerable disorder between different structures in the ensemble. A comparison with the structure of the (Ca2+)2 state indicates that the largest changes associated with ion-binding occur in the middle of helix IV and in the packing of helix III onto the remainder of the protein. The change in conformation of these helices is associated with a subtle reorganization of many residues in the hydrophobic core, including some side-chains that are up to 15 A from the ion-binding site.
- Slupsky CM, Kay CM, Reinach FC, Smillie LB, Sykes BD
- Calcium-induced dimerization of troponin C: mode of interaction and use of trifluoroethanol as a denaturant of quaternary structure.
- Biochemistry. 1995; 34: 7365-75
- Display abstract
Protein aggregation can be a problem, especially as a large number of proteins become available for structural studies at fairly high concentrations using solution techniques such as NMR spectroscopy. The muscle regulatory protein troponin C (TnC) undergoes a calcium-induced dimerization at neutral pH with a dissociation constant for the dimerization of 0.4 mM at 20 degrees C. The present study indicates that the mode of dimerization involves the N-domain of one monomer interacting with the N-domain of another monomer. Addition of the solvent trifluoroethanol (TFE) to a concentration of 15%, v/v, results in a 10-fold increase in the dimer dissociation constant of calcium-saturated TnC (4 mM at 20 degrees C), making TnC predominantly a monomer for spectroscopic studies. Further, TFE, at the concentrations used herein, acts to perturb the quaternary structure of TnC without adversely affecting the secondary or tertiary structure as evidenced by minimal changes to its CD spectra and 1H, 13C, and 15N NMR chemical shifts.
- Slupsky CM, Reinach FC, Smillie LB, Sykes BD
- Solution secondary structure of calcium-saturated troponin C monomer determined by multidimensional heteronuclear NMR spectroscopy.
- Protein Sci. 1995; 4: 1279-90
- Display abstract
The solution secondary structure of calcium-saturated skeletal troponin C (TnC) in the presence of 15% (v/v) trifluoroethanol (TFE), which has been shown to exist predominantly as a monomer (Slupsky CM, Kay CM, Reinach FC, Smillie LB, Sykes BD, 1995, Biochemistry 34, forthcoming), has been investigated using multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The 1H, 15N, and 13C NMR chemical shift values for TnC in the presence of TFE are very similar to values obtained for calcium-saturated NTnC (residues 1-90 of skeletal TnC), calmodulin, and synthetic peptide homodimers. Moreover, the secondary structure elements of TnC are virtually identical to those obtained for calcium-saturated NTnC, calmodulin, and the synthetic peptide homodimers, suggesting that 15% (v/v) TFE minimally perturbs the secondary and tertiary structure of this stably folded protein. Comparison of the solution structure of calcium-saturated TnC with the X-ray crystal structure of half-saturated TnC reveals differences in the phi/psi angles of residue Glu 41 and in the linker between the two domains. Glu 41 has irregular phi/psi angles in the crystal structure, producing a kink in the B helix, whereas in calcium-saturated TnC, Glu 41 has helical phi/psi angles, resulting in a straight B helix. The linker between the N and C domains of calcium-saturated TnC is flexible in the solution structure.
- Gagne SM, Tsuda S, Li MX, Chandra M, Smillie LB, Sykes BD
- Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C.
- Protein Sci. 1994; 3: 1961-74
- Display abstract
The backbone resonance assignments have been completed for the apo (1H and 15N) and calcium-loaded (1H, 15N, and 13C) regulatory N-domain of chicken skeletal troponin-C (1-90), using multidimensional homonuclear and heteronuclear NMR spectroscopy. The chemical-shift information, along with detailed NOE analysis and 3JHNH alpha coupling constants, permitted the determination and quantification of the Ca(2+)-induced secondary structural change in the N-domain of TnC. For both structures, 5 helices and 2 short beta-strands were found, as was observed in the apo N-domain of the crystal structure of whole TnC (Herzberg O, James MNG, 1988, J Mol Biol 203:761-779). The NMR solution structure of the apo form is indistinguishable from the crystal structure, whereas some structural differences are evident when comparing the 2Ca2+ state solution structure with the apo one. The major conformational change observed is the straightening of helix-B upon Ca2+ binding. The possible importance and role of this conformational change is explored. Previous CD studies on the regulatory domain of TnC showed a significant Ca(2+)-induced increase in negative ellipticity, suggesting a significant increase in helical content upon Ca2+ binding. The present study shows that there is virtually no change in alpha-helical content associated with the transition from apo to the 2Ca2+ state of the N-domain of TnC. Therefore, the Ca(2+)-induced increase in ellipticity observed by CD does not relate to a change in helical content, but more likely to changes in spatial orientation of helices.
- Skelton NJ, Kordel J, Akke M, Forsen S, Chazin WJ
- Signal transduction versus buffering activity in Ca(2+)-binding proteins.
- Nat Struct Biol. 1994; 1: 239-45
- Display abstract
The three-dimensional structure of calbindin D9k in the absence of Ca2+ has been determined using NMR spectroscopy in solution, allowing the first direct analysis of the consequences of Ca2+ binding for a member of the calmodulin superfamily of proteins. The overall response in calbindin D9k is much attenuated relative to the current model for calmodulin and troponin C. These results demonstrate a novel mechanism for modulating the conformational response to Ca(2+)-binding in calmodulin superfamily proteins and provide insights into how their Ca(2+)-binding domains can be fine-tuned to remain essentially intact or respond strongly to ion binding, in relation to their functional requirements.
- Kordel J, Skelton NJ, Akke M, Chazin WJ
- High-resolution structure of calcium-loaded calbindin D9k.
- J Mol Biol. 1993; 231: 711-34
- Display abstract
The three-dimensional solution structure of calcium-loaded calbindin D9k has been determined using experimental constraints obtained from nuclear magnetic resonance spectroscopy. A total of 1176 constraints (16 per residue overall, 32 per residue for the core residues) was used for the final refinement, including 1002 distance and 174 dihedral angle constraints. In addition, 23 hydrogen bond constraints were used for the generation of initial structures. Stereospecific assignments were made for 37 of 61 (61%) prochiral methylene protons and the methyl groups of all three valine residues and five out of 12 leucine residues. These constraints were used as input for a series of calculations of three-dimensional structures using a combination of distance geometry and restrained molecular dynamics. The 33 best structures selected for further analysis have no distance constraint violations greater than 0.3 A and good local geometries as reflected by low total energies (< or = -1014 kcal/mol in the AMBER 4.0 force field). The core of the protein consists of four well-defined helices with root-mean-square deviations from the average of 0.45 A for the N, C alpha and C' backbone atoms. These helices are packed in an antiparallel fashion to form two helix-loop-helix calcium-binding motifs, termed EF-hands. The two EF-hands are joined at one end by a ten-residue linker segment, and at the other by a short beta-type interaction between the two calcium-binding loops. Overall, the average solution structure of calbindin D9k is very similar to the crystal structure, with a pairwise root-mean-square deviation of 0.85 A for the N, C alpha and C' backbone atoms of the four helices. The differences that are observed between the solution and the crystal structures are attributed to specific crystal contacts, increased side-chain flexibility in solution, or artifacts arising from molecular dynamics refinement of the solution structures in vacuo.
- Watterson DM, HarrelsonWGJ r, Keller PM, Sharief F, Vanaman TC
- Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.
- J Biol Chem. 1976; 251: 4501-13
- Display abstract
Results of studies of the Ca2+-dependent protein modulator of 3':5'-cyclic nucleotide phosphodiesterase isolated from bovine brain are presented which show its structural similarity to the Ca2+-binding subunit of muscle troponin. Both proteins have blocked NH2 termini, similar and characteristic ultraviolet absorption spectra, similar Ca2+-binding properties, very similar amino acid compositions, and co-migrate on sodium dodecyl sulfate-polyacrylamide gels. The primary structures of selected tryptic peptides isolated from bovine brain modulator protein are similar or identical with regions of the primary sequences of rabbit skeletal muscle and bovine cardiac muscle troponin C. Bovine brain modulator protein contains and unidentified ninhydrin-positive basic compound not found in muscle troponin C. An improved procedure is presented which yields 40 to 70 mg of modulator protein per kg of bovine brain.
- Kretsinger RH
- Gene triplication deduced from the tertiary structure of a muscle calcium binding protein.
- Nat New Biol. 1972; 240: 85-8
- McLachlan AD
- Gene duplication in carp muscle calcium binding protein.
- Nat New Biol. 1972; 240: 83-5
- Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the EFh domain.
Protein Disease Calpain-3 (P20807) (SMART) OMIM:114240: Muscular dystrophy, limb-girdle, type 2A
- Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
% proteins involved KEGG pathway ID Description 8.58 map04020 Calcium signaling pathway 7.04 map04510 Focal adhesion 6.27 map04810 Regulation of actin cytoskeleton 6.27 map04530 Tight junction 6.01 map04070 Phosphatidylinositol signaling system 5.41 map04720 Long-term potentiation 4.72 map04740 Olfactory transduction 4.12 map04210 Apoptosis 3.52 map04010 MAPK signaling pathway 3.26 map04670 Leukocyte transendothelial migration 3.00 map04520 Adherens junction 2.92 map05214 Glioma 2.92 map04916 Melanogenesis 2.92 map04912 GnRH signaling pathway 2.92 map04910 Insulin signaling pathway 2.92 map05040 Huntington's disease 2.83 map00562 Inositol phosphate metabolism 2.75 map00564 Glycerophospholipid metabolism 2.49 map04370 VEGF signaling pathway 2.49 map04662 B cell receptor signaling pathway 2.49 map04310 Wnt signaling pathway 2.49 map04360 Axon guidance 2.49 map04660 T cell receptor signaling pathway 2.49 map04650 Natural killer cell mediated cytotoxicity 1.72 map00561 Glycerolipid metabolism 1.63 map00632 Benzoate degradation via CoA ligation 0.77 map00030 Pentose phosphate pathway 0.26 map00190 Oxidative phosphorylation 0.26 map00360 Phenylalanine metabolism 0.17 map00350 Tyrosine metabolism 0.17 map00340 Histidine metabolism 0.17 map00642 Ethylbenzene degradation 0.17 map00903 Limonene and pinene degradation 0.17 map00960 Alkaloid biosynthesis II 0.17 map00310 Lysine degradation 0.17 map00624 1- and 2-Methylnaphthalene degradation 0.17 map00230 Purine metabolism 0.09 map00940 Phenylpropanoid biosynthesis 0.09 map00650 Butanoate metabolism 0.09 map00680 Methane metabolism 0.09 map00280 Valine, leucine and isoleucine degradation 0.09 map00072 Synthesis and degradation of ketone bodies 0.09 map00361 gamma-Hexachlorocyclohexane degradation 0.09 map00627 1,4-Dichlorobenzene degradation 0.09 map00364 Fluorobenzoate degradation
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EFh domain which could be assigned to a KEGG orthologous group, and not all proteins containing EFh domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of EFh domains in PDB
PDB code Main view Title 1a29 Calmodulin complexed with trifluoperazine (1:2 complex) 1a2x Complex of troponin c with a 47 residue (1-47) fragment of troponin i 1a75 Whiting parvalbumin 1ahr Calmodulin mutant with a two residue deletion in the central helix 1aj4 Structure of calcium-saturated cardiac troponin c, nmr, 1 structure 1aj5 Calpain domain vi apo 1ak8 Nmr solution structure of cerium-loaded calmodulin amino- terminal domain (ce2-tr1c), 23 structures 1alv Calcium bound domain vi of porcine calpain 1alw Inhibitor and calcium bound domain vi of porcine calpain 1ap4 Regulatory domain of human cardiac troponin c in the calcium-saturated state, nmr, 40 structures 1aui Human calcineurin heterodimer 1avs X-ray crystallographic study of calcium-saturated n- terminal domain of troponin c 1b7t Myosin digested by papain 1b8r Parvalbumin 1b9a Parvalbumin (mutation;d51a, f102w) 1bjf Crystal structure of recombinant bovine neurocalcin delta at 2.4 angstroms 1blq Structure and interaction site of the regulatory domain of troponin-c when complexed with the 96-148 region of troponin-i, nmr, 29 structures 1boc The solution structures of mutant calbindin d9k's, as determined by nmr, show that the calcium binding site can adopt different folds 1bod The solution structures of mutant calbindin d9k's, as determined by nmr, show that the calcium binding site can adopt different folds 1br1 Smooth muscle myosin motor domain-essential light chain complex with mgadp.alf4 bound at the active site 1br4 Smooth muscle myosin motor domain-essential light chain complex with mgadp.bef3 bound at the active site 1bu3 Refined crystal structure of calcium-bound silver hake (pi 4.2) parvalbumin at 1.65 a. 1c7v Nmr solution structure of the calcium-bound c-terminal domain (w81-s161) of calcium vector protein from amphioxus 1c7w Nmr solution structure of the calcium-bound c-terminal domain (w81-s161) of calcium vector protein from amphioxus 1cdl Target enzyme recognition by calmodulin: 2.4 angstroms structure of a calmodulin-peptide complex 1cdm Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures 1cdp Restrained least squares refinement of native (calcium) and cadmium-substituted carp parvalbumin using x-ray crystallographic data at 1.6-angstroms resolution 1cfc Calcium-free calmodulin 1cfd Calcium-free calmodulin 1cff Nmr solution structure of a complex of calmodulin with a binding peptide of the ca2+-pump 1ckk Calmodulin/rat ca2+/calmodulin dependent protein kinase fragment 1cll Calmodulin structure refined at 1.7 angstroms resolution 1clm Structure of paramecium tetraurelia calmodulin at 1.8 angstroms resolution 1cm1 Motions of calmodulin-single-conformer refinement 1cm4 Motions of calmodulin-four-conformer refinement 1cmf Nmr solution structure of apo calmodulin carboxy-terminal domain 1cmg Nmr solution structure of calcium-loaded calmodulin carboxy- terminal domain 1ctr Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex 1deg The linker of des-glu84 calmodulin is bent as seen in the crystal structure 1df0 Crystal structure of m-calpain 1dfk Nucleotide-free scallop myosin s1-near rigor state 1dfl Scallop myosin s1 complexed with mgadp:vanadate-transition state 1dgu Homology-based model of calcium-saturated cib (calcium-and integrin-binding protein) 1dgv Homology-based model of apo cib (calcium-and integrin- binding protein) 1djg Phosphoinositide-specific phospholipase c-delta1 from rat complexed with lanthanum 1djh Phosphoinositide-specific phospholipase c-delta1 from rat complexed with barium 1dji Phosphoinositide-specific phospholipase c-delta1 from rat complexed with calcium 1djw Phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-2-methylene-1,2-cyclic- monophosphonate 1djx Phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-1,4,5-trisphosphate 1djy Phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-2,4,5-trisphosphate 1djz Phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-4,5-bisphosphate 1dmo Calmodulin, nmr, 30 structures 1dtl Crystal structure of calcium-saturated (3ca2+) cardiac troponin c complexed with the calcium sensitizer bepridil at 2.15 a resolution 1dvi Calpain domain vi with calcium bound 1ej3 Crystal structure of aequorin 1el4 Structure of the calcium-regulated photoprotein obelin determined by sulfur sas 1exr The 1.0 angstrom crystal structure of ca+2 bound calmodulin 1f4o Crystal structure of grancalcin with bound calcium 1f4q Crystal structure of apo grancalcin 1f54 Solution structure of the apo n-terminal domain of yeast calmodulin 1f55 Solution structure of the calcium bound n-terminal domain of yeast calmodulin 1f70 Refined solution structure of calmodulin n-terminal domain 1f71 Refined solution structure of calmodulin c-terminal domain 1fi5 Nmr structure of the c terminal domain of cardiac troponin c bound to the n terminal domain of cardiac troponin i. 1fpw Structure of yeast frequenin 1fw4 Crystal structure of e. coli fragment tr2c from calmodulin to 1.7 a resolution 1g33 Crystal structure of rat parvalbumin without the n-terminal domain 1g4y 1.60 a crystal structure of the gating domain from small conductance potassium channel complexed with calcium- calmodulin 1g8i Crystal structure of human frequenin (neuronal calcium sensor 1) 1ggw Cdc4p from schizosaccharomyces pombe 1ggz Crystal structure of the calmodulin-like protein (hclp) from human epithelial cells 1gjy The x-ray structure of the sorcin calcium binding domain (scbd) provides insight into the phosphorylation and calcium dependent processess 1h4b Solution structure of the birch pollen allergen bet v 4 1hqv Structure of apoptosis-linked protein alg-2 1i84 Cryo-em structure of the heavy meromyosin subfragment of chicken gizzard smooth muscle myosin with regulatory light chain in the dephosphorylated state. only c alphas provided for regulatory light chain. only backbone atoms provided for s2 fragment. 1ih0 Structure of the c-domain of human cardiac troponin c in complex with ca2+ sensitizer emd 57033 1ij5 Metal-free structure of multidomain ef-hand protein, cbp40, from true slime mold 1ij6 Ca2+-bound structure of multidomain ef-hand protein, cbp40, from true slime mold 1iku Myristoylated recoverin in the calcium-free state, nmr, 22 structures 1iq5 Calmodulin/nematode ca2+/calmodulin dependent kinase kinase fragment 1iwq Crystal structure of marcks calmodulin binding domain peptide complexed with ca2+/calmodulin 1j1d Crystal structure of the 46kda domain of human cardiac troponin in the ca2+ saturated form 1j1e Crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 1j7o Solution structure of calcium-calmodulin n-terminal domain 1j7p Solution structure of calcium calmodulin c-terminal domain 1jba Unmyristoylated gcap-2 with three calcium ions bound 1jc2 Complex of the c-domain of troponin c with residues 1-40 of troponin i 1jf0 The crystal structure of obelin from obelia geniculata at 1.82 a resolution 1jf2 Crystal structure of w92f obelin mutant from obelia longissima at 1.72 angstrom resolution 1jfj Nmr solution structure of an ef-hand calcium binding protein from entamoeba histolytica 1jfk Minimum energy representative structure of a calcium bound ef-hand protein from entamoeba histolytica 1jsa Myristoylated recoverin with two calciums bound, nmr, 24 structures 1juo Crystal structure of calcium-free human sorcin: a member of the penta-ef-hand protein family 1k90 Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy- atp 1k93 Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 1k94 Crystal structure of des(1-52)grancalcin with bound calcium 1k95 Crystal structure of des(1-52)grancalcin with bound calcium 1k9u Crystal structure of the calcium-binding pollen allergen phl p 7 (polcalcin) at 1.75 angstroem 1kfu Crystal structure of human m-calpain form ii 1kfx Crystal structure of human m-calpain form i 1kk7 Scallop myosin in the near rigor conformation 1kk8 Scallop myosin (s1-adp-befx) in the actin-detached conformation 1kqm Scallop myosin s1-amppnp in the actin-detached conformation 1kwo Scallop myosin s1-atpgammas-p-pdm in the actin-detached conformation 1l2o Scallop myosin s1-adp-p-pdm in the actin-detached conformation 1l7z Crystal structure of ca2+/calmodulin complexed with myristoylated cap-23/nap-22 peptide 1la0 Solution structure of calcium saturated cardiac troponin c in the troponin c-troponin i complex 1la3 Solution structure of recoverin mutant, e85q 1lin Calmodulin complexed with trifluoperazine (1:4 complex) 1lkj Nmr structure of apo calmodulin from yeast saccharomyces cerevisiae 1lvc Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 2' deoxy, 3' anthraniloyl atp 1lxf Structure of the regulatory n-domain of human cardiac troponin c in complex with human cardiac troponin-i(147- 163) and bepridil 1m39 Solution structure of the c-terminal fragment (f86-i165) of the human centrin 2 in calcium saturated form 1m45 Crystal structure of mlc1p bound to iq2 of myo2p, a class v myosin 1m46 Crystal structure of mlc1p bound to iq4 of myo2p, a class v myosin 1m63 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes 1m8q Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1mf8 Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin 1mux Solution nmr structure of calmodulin/w-7 complex: the basis of diversity in molecular recognition, 30 structures 1mvw Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1mxe Structure of the complex of calmodulin with the target sequence of camki 1mxl Structure of cardiac troponin c-troponin i complex 1n0y Crystal structure of pb-bound calmodulin 1n2d Ternary complex of mlc1p bound to iq2 and iq3 of myo2p, a class v myosin 1ncx Troponin c 1ncy Troponin-c, complex with manganese 1ncz Troponin c 1niw Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin 1np8 18-k c-terminally trunucated small subunit of calpain 1npq Structure of a rhodamine-labeled n-domain troponin c mutant (ca2+ saturated) in complex with skeletal troponin i 115- 1nwd Solution structure of ca2+/calmodulin bound to the c- terminal domain of petunia glutamate decarboxylase 1nx0 Structure of calpain domain 6 in complex with calpastatin dic 1nx1 Calpain domain vi complexed with calpastatin inhibitory domain c (dic) 1nx2 Calpain domain vi 1nx3 Calpain domain vi in complex with the inhibitor pd150606 1nya Nmr solution structure of calerythrin, an ef-hand calcium- binding protein 1o18 Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o19 Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1a Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1b Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1c Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1d Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1e Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1f Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1o1g Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle 1oe9 Crystal structure of myosin v motor with essential light chain - nucleotide-free 1omd Structure of oncomodulin refined at 1.85 angstroms resolution. an example of extensive molecular aggregation via ca2+ 1omr Non-myristoylated wild-type bovine recoverin with calcium bound to ef-hand 3 1omv Non-myristoylated bovine recoverin (e85q mutant) with calcium bound to ef-hand 3 1ooj Structural genomics of caenorhabditis elegans : calmodulin 1oqp Structure of the ca2+/c-terminal domain of caltractin in complex with the cdc31p-binding domain from kar1p 1osa Crystal structure of recombinant paramecium tetraurelia calmodulin at 1.68 angstroms resolution 1ozs C-domain of human cardiac troponin c in complex with the inhibitory region of human cardiac troponin i 1pal Ionic interactions with parvalbumins. crystal structure determination of pike 4.10 parvalbumin in four different ionic environments 1pk0 Crystal structure of the ef3-cam complexed with pmeapp 1prw Crystal structure of bovine brain ca++ calmodulin in a compact form 1pva Comparison between the crystal and the solution structures of the ef hand parvalbumin (alpha component from pike muscle) 1pvb X-ray structure of a new crystal form of pike 4.10 parvalbumin 1q80 Solution structure and dynamics of nereis sarcoplasmic calcium binding protein 1qas 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 1qat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta complex with samarium (iii) chloride 1qiv Calmodulin complexed with n-(3,3,-diphenylpropyl)-n'-[1-r-( 3,4-bis-butoxyphenyl)-ethyl]-propylenediamine (dpd), 1:2 complex 1qiw Calmodulin complexed with n-(3,3,-diphenylpropyl)-n'-[1-r-( 3,4-bis-butoxyphenyl)-ethyl]-propylenediamine (dpd) 1qs7 The 1.8 angstrom structure of calmodulin rs20 peptide complex 1qtx The 1.65 angstrom structure of calmodulin rs20 peptide complex 1qv0 Atomic resolution structure of obelin from obelia longissima 1qv1 Atomic resolution structure of obelin from obelia longissima 1qvi Crystal structure of scallop myosin s1 in the pre-power stroke state to 2.6 angstrom resolution: flexibility and function in the head 1qx5 Crystal structure of apocalmodulin 1qx7 Crystal structure of apocam bound to the gating domain of small conductance ca2+-activated potassium channel 1qxp Crystal structure of a mu-like calpain 1r2u Nmr structure of the n domain of trout cardiac troponin c at 30 c 1r6p Nmr structure of the n-terminal domain of trout cardiac troponin c at 7 c 1rec Three-dimensional structure of recoverin, a calcium sensor in vision 1rfj Crystal structure of potato calmodulin pcm6 1rjv Solution structure of human alpha-parvalbumin refined with a paramagnetism-based strategy 1rk9 Solution structure of human alpha-parvalbumin (minimized average structure) 1rro Refinement of recombinant oncomodulin at 1.30 angstroms resolution 1rtp Refined x-ray structure of rat parvalbumin, a mammalian alpha-lineage parvalbumin, at 2.0 a resolution 1rwy Crystal structure of rat alpha-parvalbumin at 1.05 resolution 1s1e Crystal structure of kv channel-interacting protein 1 (kchip-1) 1s26 Structure of anthrax edema factor-calmodulin-alpha,beta- methyleneadenosine 5'-triphosphate complex reveals an alternative mode of atp binding to the catalytic site 1s36 Crystal structure of a ca2+-discharged photoprotein: implications for the mechanisms of the calcium trigger and the bioluminescence 1s3p Crystal structure of rat alpha-parvalbumin s55d/e59d mutant 1s5g Structure of scallop myosin s1 reveals a novel nucleotide conformation 1s6c Crystal structure of the complex between kchip1 and kv4.2 n1-30 1s6i Ca2+-regulatory region (cld) from soybean calcium-dependent protein kinase-alpha (cdpk) in the presence of ca2+ and the junction domain (jd) 1s6j N-terminal region of the ca2+-saturated calcium regulatory domain (cld) from soybean calcium-dependent protein kinase- alpha (cdpk) 1sbj Nmr structure of the mg2+-loaded c terminal domain of cardiac troponin c bound to the n terminal domain of cardiac troponin i 1scm Structure of the regulatory domain of scallop myosin at 2.8 angstroms resolution 1scv Nmr structure of the c terminal domain of cardiac troponin c bound to the n terminal domain of cardiac troponin i 1sjj Cryo-em structure of chicken gizzard smooth muscle alpha- actinin 1sk6 Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin, 3',5' cyclic amp (camp), and pyrophosphate 1skt Solution structure of apo n-domain of troponin c, nmr, 40 structures 1sl7 Crystal structure of calcium-loaded apo-obelin from obelia longissima 1sl8 Calcium-loaded apo-aequorin from aequorea victoria 1sl9 Obelin from obelia longissima 1smg Calcium-bound e41a mutant of the n-domain of chicken troponin c, nmr, 40 structures 1spy Regulatory domain of human cardiac troponin c in the calcium-free state, nmr, 40 structures 1sr6 Structure of nucleotide-free scallop myosin s1 1sw8 Solution structure of the n-terminal domain of human n60d calmodulin refined with paramagnetism based strategy 1sy9 Structure of calmodulin complexed with a fragment of the olfactory cng channel 1tcf Crystal structure of calcium-saturated rabbit skeletal troponin c 1tco Ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus) 1tiz Solution structure of a calmodulin-like calcium-binding domain from arabidopsis thaliana 1tn4 Four calcium tnc 1tnp Structures of the apo and calcium troponin-c regulatory domains: the muscle contraction switch 1tnq Structures of the apo and calcium troponin-c regulatory domains: the muscle contraction switch 1tnw Nmr solution structure of calcium saturated skeletal muscle troponin c 1tnx Nmr solution structure of calcium saturated skeletal muscle troponin c 1top Structure of chicken skeletal muscle troponin-c at 1.78 angstroms resolution 1trf Solution structure of the tr1c fragment of skeletal muscle troponin-c 1ttx Solution stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy 1u5i Crystal structure analysis of rat m-calpain mutant lys10 thr 1uhh Crystal structure of cp-aequorin 1uhi Crystal structure of i-aequorin 1uhj Crystal structure of br-aequorin 1uhk Crystal structure of n-aequorin 1uhn The crystal structure of the calcium binding protein atcbl2 from arabidopsis thaliana 1up5 Chicken calmodulin 1v1f Structure of the arabidopsis thaliana sos3 complexed with calcium(ii) and manganese(ii) ions 1v1g Structure of the arabidopsis thaliana sos3 complexed with calcium(ii) ion 1vrk The 1.9 angstrom structure of e84k-calmodulin rs20 peptide complex 1w7i Crystal structure of myosin v motor without nucleotide soaked in 10 mm mgadp 1w7j Crystal structure of myosin v motor with essential light chain + adp-befx - near rigor 1wdc Scallop myosin regulatory domain 1wrk Crystal structure of the n-terminal domain of human cardiac troponin c in complex with trifluoperazine (orthrombic crystal form) 1wrl Crystal structure of the n-terminal domain of human cardiac troponin c in complex with trifluoperazine (monoclinic crystal form) 1wrz Calmodulin complexed with a peptide from a human death- associated protein kinase 1x02 Solution structure of stereo array isotope labeled (sail) calmodulin 1xa5 Structure of calmodulin in complex with kar-2, a bis-indol alkaloid 1xfu Crystal structure of anthrax edema factor (ef) truncation mutant, ef-delta 64 in complex with calmodulin 1xfv Crystal structure of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy-atp 1xfw Crystal structure of anthrax edema factor (ef) in complex with calmodulin and 3'5' cyclic amp (camp) 1xfx Crystal structure of anthrax edema factor (ef) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride 1xfy Crystal structure of anthrax edema factor (ef) in complex with calmodulin 1xfz Crystal structure of anthrax edema factor (ef) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride 1xo5 Crystal structure of cib1, an ef-hand, integrin and kinase- binding protein 1xvj Crystal structure of rat alpha-parvalbumin d94s/g98e mutant 1y0v Crystal structure of anthrax edema factor (ef) in complex with calmodulin and pyrophosphate 1y1a Crystal structure of calcium and integrin binding protein 1y1x Structural analysis of a homolog of programmed cell death 6 protein from leishmania major friedlin 1y6w Trapped intermediate of calmodulin 1yr5 1.7-a structure of calmodulin bound to a peptide from dap kinase 1yrt Crystal structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of bordetella pertussis in presence of c-terminal calmodulin 1yru Crystal structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of bordetella pertussis in presence of c-terminal calmodulin and 1mm calcium chloride 1ytz Crystal structure of skeletal muscle troponin in the ca2+- activated state 1yv0 Crystal structure of skeletal muscle troponin in the ca2+- free state 1yx7 Nmr structure of calsensin, energy minimized average structure. 1yx8 Nmr structure of calsensin, 20 low energy structures. 1zac N-domain of troponin c from chicken skeletal muscle, nmr, minimized average structure 1zmz Solution structure of the n-terminal domain (m1-s98) of human centrin 2 1zot Crystal structure analysis of the cyaa/c-cam with pmeapp 1zuz Calmodulin in complex with a mutant peptide from human drp- kinase 2a4j Solution structure of the c-terminal domain (t94-y172) of the human centrin 2 in complex with a 17 residues peptide (p1-xpc) from xeroderma pigmentosum group c protein 2aao Regulatory apparatus of calcium dependent protein kinase from arabidopsis thaliana 2ami Solution structure of the calcium-loaded n-terminal sensor domain of centrin 2b1u Solution structure of calmodulin-like skin protein c terminal domain 2bbm Solution structure of a calmodulin-target peptide complex by multidimensional nmr 2bbn Solution structure of a calmodulin-target peptide complex by multidimensional nmr 2bcx Crystal structure of calmodulin in complex with a ryanodine receptor peptide 2be4 X-ray structure an ef-hand protein from danio rerio dr.36843 2be6 2.0 a crystal structure of the cav1.2 iq domain-ca/cam complex 2bec Crystal structure of chp2 in complex with its binding region in nhe1 and insights into the mechanism of ph regulation 2bkh Myosin vi nucleotide-free (mdinsert2) crystal structure 2bki Myosin vi nucleotide-free (mdinsert2-iq) crystal structure 2bl0 Physarum polycephalum myosin ii regulatory domain 2ccm X-ray structure of calexcitin from loligo pealeii at 1.8a 2col Crystal structure analysis of cyaa/c-cam with pyrophosphate 2ct9 The crystal structure of calcineurin b homologous proein 1 (chp1) 2ctn Structure of calcium-saturated cardiac troponin c, nmr, 30 structures 2d8n Crystal structure of human recoverin at 2.2 a resolution 2dfs 3-d structure of myosin-v inhibited state 2doq Crystal structure of sfi1p/cdc31p complex 2e30 Solution structure of the cytoplasmic region of na+/h+ exchanger 1 complexed with essential cofactor calcineurin b homologous protein 1 2e6w Solution structure and calcium binding properties of ef- hands 3 and 4 of calsenilin 2ec6 Placopecten striated muscle myosin ii 2ehb The structure of the c-terminal domain of the protein kinase atsos2 bound to the calcium sensor atsos3 2ekv The crystal structure of rigor like squid myosin s1 in the absence of nucleotide 2ekw The crystal structure of squid myosin s1 in the presence of so4 2- 2eqc Solution structure of magnesium-bound form of calmodulin c- domain e104d/e140d mutant 2f2o Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode 2f2p Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode 2f33 Nmr solution structure of ca2+-loaded calbindin d28k 2f3y Calmodulin/iq domain complex 2f3z Calmodulin/iq-aa domain complex 2f8p Crystal structure of obelin following ca2+ triggered bioluminescence suggests neutral coelenteramide as the primary excited state 2fce Solution structure of c-lobe myosin light chain from saccharomices cerevisiae 2fot Crystal structure of the complex between calmodulin and alphaii-spectrin 2g9b Nmr solution structure of ca2+-loaded calbindin d28k 2ggm Human centrin 2 xeroderma pigmentosum group c protein complex 2ggz Crystal structure of human guanylate cyclase activating protein-3 2gv5 Crystal structure of sfi1p/cdc31p complex 2het Non-myristoylated bovine recoverin (truncated at c- terminus) with calcium bound to ef-hand 3 2hf5 The structure and function of a novel two-site calcium- binding fragment of calmodulin 2hpk Crystal structure of photoprotein berovin from beroe abyssicola 2hps Crystal structure of coelenterazine-binding protein from renilla muelleri 2hq8 Crystal structure of coelenterazine-binding protein from renilla muelleri in the ca loaded apo form 2hqw Crystal structure of ca2+/calmodulin bound to nmda receptor nr1c1 peptide 2i08 Solvation effect in conformational changes of ef-hand proteins: x-ray structure of ca2+-saturated double mutant q41l-k75i of n-domain of calmodulin 2i18 The refined structure of c-terminal domain of an ef-hand calcium binding protein from entamoeba histolytica 2i2r Crystal structure of the kchip1/kv4.3 t1 complex 2i94 Nmr structure of recoverin bound to rhodopsin kinase 2isd Phosphoinositide-specific phospholipase c-delta1 from rat 2ix7 Structure of apo-calmodulin bound to unconventional myosin v 2jc2 The crystal structure of the natural f112l human sorcin mutant 2jnf Solution structure of fly troponin c, isoform f1 2jnx Nmr derived solution structure of an ef-hand calcium binding protein from entamoeba histolytica 2joj Nmr solution structure of n-terminal domain of euplotes octocarinatus centrin 2jt0 Solution structure of f104w cardiac troponin c 2jt3 Solution structure of f153w cardiac troponin c 2jt8 Solution structure of the f153-to-5-flurotryptophan mutant of human cardiac troponin c 2jtz Solution structure and chemical shift assignments of the f104-to-5-flurotryptophan mutant of cardiac troponin c 2ju0 Structure of yeast frequenin bound to pdtins 4-kinase 2jul Nmr structure of dream 2jww Calcium-free rat alpha-parvalbumin 2jxl Solution structure of cardiac n-domain troponin c mutant f77w-v82a 2jzi Structure of calmodulin complexed with the calmodulin binding domain of calcineurin 2k0e A coupled equilibrium shift mechanism in calmodulin- mediated signal transduction 2k0f Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase 2k0j Solution structure of cam complexed to drp1p 2k2a Solution structure of the apo c terminal domain of lethocerus troponin c isoform f1 2k2i Nmr solution structure of the c-terminal domain (t94-y172) of the human centrin 2 in complex with a repeat sequence of human sfi1 (r641-t660) 2k3s Haddock-derived structure of the ch-domain of the smoothelin-like 1 complexed with the c-domain of apocalmodulin 2k61 Solution structure of cam complexed to dapk peptide 2k7c Nmr structure of mg2+-bound cabp1 c-domain 2k7d Nmr structure of ca2+-bound cabp1 c-domain 2kdh The solution structure of human cardiac troponin c in complex with the green tea polyphenol; (-)- epigallocatechin-3-gallate 2kfx Structure of the n-terminal domain of human cardiac troponin c bound to calcium ion and to the inhibitor w7 2kgb Nmr solution of the regulatory domain cardiac f77w-troponin c in complex with the cardiac troponin i 144-163 switch peptide 2kn2 Solution structure of the c-terminal domain of soybean calmodulin isoform 4 fused with the calmodulin-binding domain of ntmkp1 2kne Calmodulin wraps around its binding domain in the plasma membrane ca2+ pump anchored by a novel 18-1 motif 2mys Myosin subfragment-1, alpha carbon coordinates only for the two light chains 2nln Solution structure of calcium-free rat beta-parvalbumin 2nxq Crystal structure of calcium binding protein 1 from entamoeba histolytica: a novel arrangement of ef hand motifs 2nz0 Crystal structure of potassium channel kv4.3 in complex with its regulatory subunit kchip1 (casp target) 2o5g Calmodulin-smooth muscle light chain kinase peptide complex 2o60 Calmodulin bound to peptide from neuronal nitric oxide synthase 2obh Centrin-xpc peptide 2opo Crystal structure of the calcium-binding pollen allergen che a 3 2os8 Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor 2otg Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor 2ovk Crystal structure of rigor-like squid myosin s1 2oy6 Crystal structure of squid mg.adp myosin s1 2p6b Crystal structure of human calcineurin in complex with pvivit peptide 2pal Ionic interactions with parvalbumins. crystal structure determination of pike 4.10 parvalbumin in four different ionic environments 2pas Comparison between the crystal and the solution structures of the ef hand parvalbumin 2pmy Ef-hand domain of human rasef 2pq3 N-terminal calmodulin zn-trapped intermediate 2pvb Pike parvalbumin (pi 4.10) at low temperature (100k) and atomic resolution (0.91 a). 2q4u Ensemble refinement of the crystal structure of an ef-hand protein from danio rerio dr.36843 2r28 The complex structure of calmodulin bound to a calcineurin peptide 2r2i Myristoylated guanylate cyclase activating protein-1 with calcium bound 2ro8 Solution structure of calcium bound soybean calmodulin isoform 1 n-terminal domain 2ro9 Solution structure of calcium bound soybean calmodulin isoform 1 c-terminal domain 2roa Solution structure of calcium bound soybean calmodulin isoform 4 n-terminal domain 2rob Solution structure of calcium bound soybean calmodulin isoform 4 c-terminal domain 2sas Structure of a sarcoplasmic calcium-binding protein from amphioxus refined at 2.4 angstroms resolution 2scp Structure of a sarcoplasmic calcium-binding protein from nereis diversicolor refined at 2.0 angstroms resolution 2tn4 Four calcium tnc 2v01 Recombinant vertebrate calmodulin complexed with pb 2v02 Recombinant vertebrate calmodulin complexed with ba 2vas Myosin vi (md-insert2-cam, delta-insert1) post-rigor state 2vay Calmodulin complexed with cav1.1 iq peptide 2vb6 Myosin vi (md-insert2-cam, delta insert1) post-rigor state ( crystal form 2) 2w73 High-resolution structure of the complex between calmodulin and a peptide from calcineurin a 2wel Crystal structure of su6656-bound calcium/calmodulin- dependent protein kinase ii delta in complex with calmodulin 2zfd The crystal structure of plant specific calcium binding protein atcbl2 in complex with the regulatory domain of atcipk14 2zn8 Crystal structure of zn2+-bound form of alg-2 2zn9 Crystal structure of ca2+-bound form of des3-20alg-2 2znd Crystal structure of ca2+-free form of des3-20alg-2 2zne Crystal structure of zn2+-bound form of des3-23alg-2 complexed with alix abs peptide 2zrs Crystal structure of ca2+-bound form of des3-23alg-2 2zrt Crystal structure of zn2+-bound form of des3-23alg-2 3a8r The structure of the n-terminal regulatory domain of a plant nadph oxidase 3b32 Crystal structure of calcium-saturated calmodulin n- terminal domain fragment, residues 1-75 3bow Structure of m-calpain in complex with calpastatin 3bxk Crystal structure of the p/q-type calcium channel (cav2.1) iq domain and ca2+calmodulin complex 3bxl Crystal structure of the r-type calcium channel (cav2.3) iq domain and ca2+calmodulin complex 3bya Structure of a calmodulin complex 3cln Structure of calmodulin refined at 2.2 angstroms resolution 3cs1 Flagellar calcium-binding protein (fcabp) from t. cruzi 3ctn Structure of calcium-saturated cardiac troponin c, nmr, 30 structures 3dd4 Structural basis of kchip4a modulation of kv4.3 slow inactivation 3df0 Calcium-dependent complex between m-calpain and calpastatin 3dtp Tarantula heavy meromyosin obtained by flexible docking to tarantula muscle thick filament cryo-em 3d-map 3dve Crystal structure of ca2+/cam-cav2.2 iq domain complex 3dvj Crystal structure of ca2+/cam-cav2.2 iq domain (without cloning artifact, hm to tv) complex 3dvk Crystal structure of ca2+/cam-cav2.3 iq domain complex 3dvm Crystal structure of ca2+/cam-cav2.1 iq domain complex 3e3r Crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel ef-hand- containing protein family 3ek4 Calcium-saturated gcamp2 monomer 3ek7 Calcium-saturated gcamp2 dimer 3ek8 Calcium-saturated gcamp2 t116v/g87r mutant monomer 3ekh Calcium-saturated gcamp2 t116v/k378w mutant monomer 3ekj Calcium-free gcamp2 (calcium binding deficient mutant) 3evr Crystal structure of calcium bound monomeric gcamp2 3evu Crystal structure of calcium bound dimeric gcamp2, (#1) 3evv Crystal structure of calcium bound dimeric gcamp2 (#2) 3ewt Crystal structure of calmodulin complexed with a peptide 3ewv Crystal structure of calmodulin complexed with a peptide 3f45 Structure of the r75a mutant of rat alpha-parvalbumin 3fwb Sac3:sus1:cdc31 complex 3fwc Sac3:sus1:cdc31 complex 3g43 Crystal structure of the calmodulin-bound cav1.2 c-terminal regulatory domain dimer 3gn4 Myosin lever arm 3hr4 Human inos reductase and calmodulin complex 3hx4 Crystal structure of cdpk1 of toxoplasma gondii, tgme49_101440, in presence of calcium 3hzt Crystal structure of toxoplasma gondii cdpk3, tgme49_105860 3i5f Crystal structure of squid mg.adp myosin s1 3i5g Crystal structure of rigor-like squid myosin s1 3i5h The crystal structure of rigor like squid myosin s1 in the absence of nucleotide 3i5i The crystal structure of squid myosin s1 in the presence of so4 2- 3i79 Calcium-dependent protein kinase 1 from toxoplasma gondii (tgcdpk1) 3igo Crystal structure of cryptosporidium parvum cdpk1, cgd3_920 3pal Ionic interactions with parvalbumins. crystal structure determination of pike 4.10 parvalbumin in four different ionic environments 3pat Comparison between the crystal and the solution structures of the ef hand parvalbumin 4cln Structure of a recombinant calmodulin from drosophila melanogaster refined at 2.2-angstroms resolution 4cpv Refined crystal structure of calcium-liganded carp parvalbumin 4.25 at 1.5-angstroms resolution 4pal 4tnc Refined structure of chicken skeletal muscle troponin c in the two-calcium state at 2-angstroms resolution 5cpv Restrained least squares refinement of native (calcium) and cadmium-substituted carp parvalbumin using x-ray crystallographic data at 1.6-angstroms resolution 5pal Crystal structure of the unique parvalbumin component from muscle of the leopard shark (triakis semifasciata). the first x-ray study of an alpha-parvalbumin 5tnc Refined crystal structure of troponin c from turkey skeletal muscle at 2.0 angstroms resolution
- Links (links to other resources describing this domain)
BLOCKS EF_HAND PFAM efhand INTERPRO IPR002048