EGF_likeEGF domain, unclasssified subfamily
|SMART accession number:||SM00001|
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- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing EGF_like domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with EGF_like domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing EGF_like domain in the selected taxonomic class.
- Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
% proteins involved KEGG pathway ID Description 19.93 map04512 ECM-receptor interaction 18.82 map04510 Focal adhesion 7.75 map05222 Small cell lung cancer 7.20 map04810 Regulation of actin cytoskeleton 5.17 map04330 Notch signaling pathway 4.98 map04514 Cell adhesion molecules (CAMs) 4.43 map04360 Axon guidance 2.21 map05060 Prion disease 2.03 map04670 Leukocyte transendothelial migration 1.66 map04320 Dorso-ventral axis formation 1.48 map04060 Cytokine-cytokine receptor interaction 1.48 map04012 ErbB signaling pathway 1.29 map05212 Pancreatic cancer 1.29 map04610 Complement and coagulation cascades 1.29 map04010 MAPK signaling pathway 1.29 map05215 Prostate cancer 1.29 map04340 Hedgehog signaling pathway 1.11 map05219 Bladder cancer 1.11 map05213 Endometrial cancer 1.11 map05010 Alzheimer's disease 1.11 map05214 Glioma 1.11 map05223 Non-small cell lung cancer 1.11 map04540 Gap junction 1.11 map05218 Melanoma 0.74 map00590 Arachidonic acid metabolism 0.74 map04640 Hematopoietic cell lineage 0.55 map00350 Tyrosine metabolism 0.55 map04310 Wnt signaling pathway 0.55 map00740 Riboflavin metabolism 0.55 map04916 Melanogenesis 0.55 map00310 Lysine degradation 0.55 map00950 Alkaloid biosynthesis I 0.55 map04650 Natural killer cell mediated cytotoxicity 0.37 map04350 TGF-beta signaling pathway 0.37 map04620 Toll-like receptor signaling pathway 0.18 map04520 Adherens junction 0.18 map05120 Epithelial cell signaling in Helicobacter pylori infection 0.18 map00910 Nitrogen metabolism 0.18 map04662 B cell receptor signaling pathway 0.18 map05220 Chronic myeloid leukemia 0.18 map04920 Adipocytokine signaling pathway 0.18 map00632 Benzoate degradation via CoA ligation 0.18 map00562 Inositol phosphate metabolism 0.18 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 0.18 map04210 Apoptosis 0.18 map04910 Insulin signaling pathway 0.18 map04660 T cell receptor signaling pathway 0.18 map05221 Acute myeloid leukemia 0.18 map04930 Type II diabetes mellitus
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EGF_like domain which could be assigned to a KEGG orthologous group, and not all proteins containing EGF_like domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of EGF_like domains in PDB
PDB code Main view Title 1dx5 Crystal structure of the thrombin-thrombomodulin complex 2bo2 EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium. 2bou EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium. 2box EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium. 2e26 Crystal structure of two repeat fragment of reelin 3a7q Structural basis for specific recognition of reelin by its receptors 3s8v Crystal structure of LRP6-Dkk1 complex 3s8z Crystal structure of LRP6-E3E4 4aqs Laminin beta1 LN-LE1-4 structure